Bill Gates Faces Trial In India For Illegally Testing Tribal Children With Vaccines

Bill Gates Faces Trial In India For Illegally Testing Tribal Children With Vaccines

Bill Gates Faces Trial in India for Illegally Testing Tribal Children with Vaccines

Christina Sarich
BY CHRISTINA SARICH
POSTED ON OCTOBER 13, 2014

Bill Gates IndiaHave Bill Gates and his eugenicist foundation’s crimes against humanity finally caught up with him? If the Supreme Court of India has anything to say about it, he will face the ramifications of poisoning millions of Indian children with vaccines.

A recent report published by Health Impact News shows that a vaccine empire built on lies can only go on for so long. The reports states

“While fraud and corruption are revealed on almost a daily basis now in the vaccine industry, theU.S. mainstream media continues to largely ignore such storiesOutside the U.S., however, the vaccine empires are beginning to crumble, and English versions of the news in mainstream media outlets are available via the Internet.

One such country is India, where the Bill & Melinda Gates Foundation and their vaccine empire are under fire, including a pending lawsuit currently being investigated by the India Supreme Court.”

If you aren’t aware of the key players in the vaccine mayhem being driven into African countries, they are:

  • The Bill & Melinda Gates Foundation
  • PATH (Program for Appropriate Technology in Health, funded by the Gates’ foundation), and
  • GAVI (Global Alliance for Vaccines and Immunization, also funded by the Gates’ foundation)

All four of these organizations will now be expected to explain themselves due to a writ of petition originally submitted to the Supreme Court of India in 2012, by Kalpana Mehta, Nalini Bhanot, and Dr. Rukmini Rao, which has finally been heard by the courts.

The petitioners stated:

“BMGF, PATH and WHO were criminally negligent trialling the vaccines on a vulnerable, uneducated and under-informed population school administrators, students and their parents who were not provided informed consent or advised of potential adverse effects or required to be monitored post-vaccination.”

Furthermore, though absent from most mainstream U.S. media outlets, the Economic Times of India published their report in August 2014, stating that young tribal girls were tested with HPV vaccines. This involved not a handful of children, but 16,000 individuals in Andhra Pradesh, India, where they were given the Gardasil vaccine.

KP Narayana Kumar reported that within a month of receiving the vaccine, many of the children fell ill, and by 2010, five of them had died. Another two children were reported to have died in Vadodara, Gujarat, where another 14,000 tribal children were vaccinated with another brand of the HPV vaccine, Cervarix, manufactured by GlaxoSmitheKline (GSK), who incidentally, has been accused of dumping polio virus into a Belgium river.

Consent forms to administer the HPV vaccine were ‘illegally’ signed by wardens form youth hostels, showing that the Gates’ prey on the indigent without parents. For those who had parents, most were illiterate, and the true potential dangers of the vaccines were not explained to them.

SAMA, an organization in India which promotes women’s health discovered this insidiousness, and reported it, but only now will Gates and his cronies have to answer for their misdeeds. Approximately 120 girls reported epileptic seizures, severe stomach cramps, headaches, and mood swings, of those who did not die. Other girls receiving the Gardasil vaccine have experienced infertility.

The Economic Times further reported:

“The SAMA report also said there had been cases of early onset of menstruation following the vaccination, heavy bleeding and severe menstrual cramps among many students. The standing committee pulled up the relevant state governments for the shoddy investigation into these deaths.

It said it was disturbed to find that ‘all the seven deaths were summarily dismissed as unrelated to vaccinations without in-depth investigations …’ the speculative causes were suicides, accidental drowning in well (why not suicide?), malaria, viral infections, subarachnoid hemorrhage (without autopsy) etc.”

The Bill and Melinda Gates Foundation declared their little vaccine project a total success. I guess the Supreme Court of India will decide that now.

About Christina Sarich:
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Christina Sarich is a humanitarian and freelance writer helping you to Wake up Your Sleepy Little Head, and See the Big Picture. Her blog is Yoga for the New World. Her latest book is Pharma Sutra: Healing the Body And Mind Through the Art of Yoga.

Read more: http://naturalsociety.com/bill-gates-faces-trial-india-illegally-testing-tribal-children-vaccines/#ixzz3szagOEbn
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MEASLES VACCINE: THE LIES WE TELL EACH OTHER

MEASLES VACCINE: THE LIES WE TELL EACH OTHER

getting a shot

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Feel like I’ve just been kicked in the stomach. Not the kind where you need a minute to catch your breath; the kind where you don’t sleep well for days.

The nonexistent Ebola hoax was one thing– throw $6 billion at it and it vanishes. But the follow-up – the fake measles ‘epidemic’ has triggered something no one could have predicted. Momentum. The story itself got traction – they no longer had to push it. It went viral. Measles viral.

Like all the rest of these Boutique Epidemics we have seen in recent years, the measles “outbreak” is centered on a fundamental lie: that the MMR vaccine can prevent measles. It cannot.

Worse yet, as we will see below, the MMR vaccine is the probable cause of the majority of these new measles cases.

But it takes a little study to discover that, and a little intelligence. Most people would rather believe the 140-character, push-button, soundbyte programming they’re getting from the lockstep media than do the slightest amount of independent reading and study.

But that’s not us. We shall start at the beginning:

Despite hospital dangers, 99% of infants are born healthy. Most people are healthy when they get vaccines. Does it make sense to inject healthy people with anything that can kill them or possibly make them sick in order to maintain that health? Vaccines must have a 0% chance of any harmful effects whatsoever to the recipient.

Are today’s vaccines 100% safe, with 0% side effects? Keep reading.

LET’S JUST VACCINATE EVERYBODY!

At this time, vaccines are not mandatory in the US. Why not? Why not end all the hysterical media controversy and simply pass a law saying that everyone must get the full complement of vaccines on the CDC Schedule? Why don’t they do that?

OK, no more exemptions. As of today, every man, woman and child in the whole country must get all the 69 recommended vaccines – let’s just rock it.

Most people would probably be in favor of that, statistically, with our 85% vaccination rate.

Global media would certainly be opposed, since they would lose one of their favorite goblin/scapegoats – the unvaccinated. And also one of their favorite gods: life-saving vaccines. They’d have to invent new monsters and messiahs to sell their copy.

But who cares about media? Why not just end all the emotional turmoil and make it illegal to opt out of vaccines? Just pull the plug. Vaccinate everyone. I can hear a lot of people out there salivating, saying Yeah! Let’s do it!

Well, they can’t. The FDA can’t. Obama can’t. Congress can’t. Don’t you think if they could, they would have done it by now?

OK, geniuses – why not? Think about it. Why can’t they force everyone to be vaccinated? Here’s the reason, which you will never be permitted to see in any mainstream press – one little word: liability.

If vaccines were truly mandatory by law, then the medicine-as-government monolith would be legally and financially responsible for the millions of vaccine injuries that occurred. Though faithfully kept out of public awareness, the FDA admits to over 2 million vaccine injuries since the 90s.

They also estimate that less than 10% of actual vaccine injuries are ever reported. So the real figure is enormous. Play this scenario out in all its legal and fiscal implications, and it would dwarf the $250 billion the tobacco industry paid out in the 1990s for tobacco injuries, by comparison.

EXEMPTIONS AND LIABILITY

What saves them now from liability? Exemptions. As long as there are vaccine exemptions, people can’t sue for damages, because the manufacturers can always say – well, you could have opted out. But take away the exemptions, and they would be responsible for all those millions of injured children and adults.

With us so far? OK for you to backtrack here – don’t want to lose anyone.

So, they can’t do away with exemptions altogether. Which means that any interested parent can learn about the 3 types of vaccine exemptions still available today.

Well, if exemptions are still legal in the US at this time, that brings up the idea of Informed Consent. A parent making this critical decision for the child is presented with a Controversy — two sides of the argument. Both sides citing their reasons.

To make a truly informed decision then requires the parent to look at both sides of the debate. Really study it – usually takes a few weeks. This is not just some intellectual word game here. Without exaggeration, life and death hang in the balance. Children and adults really do die from vaccines, every year. And tens of thousands are injured, many permanently.

That much is undisputed, even though restricted from most media.

But what we have observed in the new Disney Adventures in Fantasyland media circus, is that the militant Vaccinators want to end the controversy. They want to force their opinion on everyone, and remove medical freedom and the right to informed consent from the equation. Put an end to rational discourse. First Amendment. Just like Hitler, Ho Chi Minh, Kim Jong-un, Pol Pot, Nikolai Lenin, etc – don’t just eliminate the opposing argument – get rid of the whole concept of debate itself.

Look how they demonized New Jersey’s governor last week, when all he said was ‘strike a balance between parental choice’ and public health. All he did was acknowledge the existence of exemptions, and now media is drawing battle lines between him and Obama, who always always cheerleads for any pharmaceutical lobby. Low-end yellow journalism – conjure up an issue where none exists.

Three days later they’re investigating him for corruption.

The worst attack on medical freedom in the US has just been introduced into the California legislature, that would abolish the 40-year-old personal beliefs exemption. The bill has a lot of support and political capital, riding the tails of the recent measles hysteria.

There has been no new science. This legislation is based 100% on a nonexistent, media-created threat.

DAY OF INFAMY – ILLEGAL TO REFUSE MEDICINE

The passage of the new bill in California to abolish parents’ right to choose to vaccinate would be a quantum policy shift – an unprecedented disaster not only for medical freedom, but furthering the ongoing negation of constitutionally guaranteed personal rights.

We’re talking about making it illegal to refuse drugs for perfectly healthy people.

Making it illegal to refuse drugs is not something that has happened overnight, but little by little, step by step. This new bill will be a giant advance in that erosion of personal freedom that has been inexorably progressing since 9/11, always under the tricky old banner of security, security, security.

The Holocaust didn’t happen overnight either. It took 10 years of slow and steady stripping away of the Jews’ freedoms. No one objected. Then finally one day the trains arrived.

NO NEW SCIENCE

Remember, there has been no new science conducted, no breakthrough discovery to necessitate such a radical policy shift as to abolish people’s right to refuse drugs and vaccines.

This current measles outbreak is at the very least extremely suspicious, not significant, and almost completely engineered by a coordinated effort of drug industry, advertising and media. It has nothing to do with safety, or health, or immunity, or protection. And everything to do with market creation and political mileage.


SCIENCE VS. ADVENTURES IN FANTASYLAND

So, that brings us to Disneyland – an apt focus for the whole discussion – global home of manufactured illusion and fantasy.

The Disney measles fanfare was timed perfectly, with the Ebola illusion having run its course in just 3 months (see #2 above) But what’s going on now is a feeding frenzy gone exponential. The chimera they invented out of nothing is now in a self-perpetuating momentum. Cyber reality eclipsed physical reality.

Science is a funny word today. In all the scripted op-ed pieces we’re seeing every day on CNN, Yahoo, Google, etc. they all have their mantras for the science of measles vaccines.

We’ve seen the soundbytes, from those with no background in medicine:

“The science is clear” (Hillary)

“vaccinations are profoundly important and a major public health benefit” (Jerry Brown)

“The science is, you know, pretty indisputable.” (Obama)

But after mentioning the word ‘science’ they will never ever cite any. Ever. Not one study, not one document, not one clinical reference – no legitimate science. They just use the word like it’s magic, like they own it, but then offer nothing to back it up.

Science? Fact is, they’re afraid to death of science. The reason they never cite any is that all the legitimate science proves the opposite of what they’re selling – that the vaccine not only does not work to protect against measles, but worse – that it is the cause of today’s atypical Disney version.

Same with all these local TV doctors and ‘personalities,’ maybe a CDC or NIH guy with the same message – the science is there, etc. Worse yet are the “science writers” of CNN, Yahoo, or Foxnews – no academic credentials, no CV, except as “science writers.”

All spouting the same groundless platitudes and cliches, over and over the same phrases.

The actual science of measles vaccine proves the polar opposite: that the current measles vaccine not only does not prevent the disease, but it is also the most likely cause of the current roster of new cases. Whenever mainstream pro-measles vaccine copy invokes the science button, it’s usually the antithesis of science — trying to ignite an emotional, uninformed religious fervor— like a revival meeting, complete with fried chicken.

THE SCIENCE

Here’s a brief summary of the actual science of measles vaccine:

Science Fact #1: Measles defined

Science Fact #2: Measles is usually a mild, self-resolving disease

Vaccination Is Not Immunization, 2015 – p 133 ff

    To make any sense when discussing measles, one must start with a history and background of measles virus and disease. Without this basic information, most people don’t even know what the whole dialog is about.

Science Fact #3: People don’t die from measles. Almost never. But they die from measles vaccine.

      An up-to-date, well-organized summary of verifiable science on measles vaccine is at a site called

Vaccine Impact

From that site:

      – CDC: zero US deaths from measles in the past 10 years
    – VAERS: 108 US deaths from measles vaccine, past 10 years

Science Fact #4: The measles vaccine does not prevent measles.

      Zhejiang province in China (population 54 million) has a 99% measles vax rate. Measles continues unchecked. Same in America, with an 85% rate. The vaccine simply doesn’t work. Worse, it perpetuates the new mutated version of the disease, not just in the US, but worldwide. (PubMed:

www.ncbi.nlm.nih.gov/pubmed/24586717

    )

Science Fact #5:
There is no single measles vaccine available in the US.

    Everybody has to get the MMR shot: measles-mumps-rubella. The mumps portion of that vaccine has been in litigation in US district court for fraud for 5 years. That case is undecided, but the MMR shot continues for every child, with the presumption of safety.

Science Fact #6:
Measles was 95% gone before the MMR vaccine began in 1978.

      – US Dept of Commerce.

Historical Statistics of the U.S.

      Part 1
      Bureau of Census 1975. also

Vital Statistics of the US

    , 1937-1992

Science Fact #7: We never needed a measles vaccine.

      For over a century, measles has been a mild, self-limiting, immune-building disease of childhood. Parents wanted their children to get it so they would have lifetime immunity.

Without the vaccine, measles would have faded away completely, like smallpox, bubonic plague, and typhus.

With the MMR shot mandated in 1978, measles was resurrected but mutated to a different form – the atypical version. Manmade. This is likely what most of the new Disney cases have. Remember – they’ve mostly all been vaccinated. This is a group of vaccinated people.

Any media story on measles vaccine which omits this science is deliberately misrepresenting the facts. It’s not newsgathering any more – they are following a vested agenda.

DISNEY DOUBTS

These 100 cases being claimed as having originated from Disneyland – a few obvious questions about them occur immediately:

– How were they diagnosed?

– Were they diagnosed?

– What percentage were diagnosed on the phone, with no physical examination? This common practice we saw with swine flu and other recent disappearing epidemics, employed when trying to create numbers for maximum fear value.

– What clinical tests were run that would distinguish wild measles from the manmade strain in the MMR shot?

– What percentage were vaccinated?

Statistically it would be at least 85%, at the very least. And with the scientific reality of the atypical version of measles being created by the MMR vaccine, it is more than likely that majority of the Disney cases were vaccinated.

NATURAL SELECTION

As the sickest of all industrialized nations, what assures our uninterrupted de-evolution is the decline of intelligence and education where perfectly healthy people willingly accept being forced to take potentially dangerous drugs and vaccines. Without a squawk.

Exempting one’s child from vaccines has always been a path chosen by a small percentage of the most educated people. The militantly uneducated will always accept as many vaccines as they are told. That will never change.

What has changed dramatically is that now we have arrived at a dangerous and uncharted new crossroads in national politics, where the will of the uneducated mob is being imposed by law on the educated. Such a trend will ensure the continuation of the academic, ethical, and moral deterioration that we have witnessed since 9/11. Today’s measles hysteria is just a symptom of that more systemic, more profound malaise.

CLARENCE DARROW

The unvaccinated don’t care what the vaccinated do, or what they read. But now suddenly the vaccinators want to take away the right of anyone to disagree with their beliefs, and even the right to study the issue.

It all comes back to Clarence Darrow, attorney of 100 years ago. His question still holds true: OK, some people want to vaccinate and some do not. But why do the vaccinated care if some go unvaccinated? Aren’t their vaccinated children protected? Don’t their vaccines work?

The vaccinators cannot answer that question. They don’t understand it. Their faces go blank when asked it. They change the subject and absolutely will not answer the question. They demand to have their opinion on vaccines, but refuse to allow an opposite opinion, even though both positions are protected by law.

ADVICE TO THE UNVACCINATED

Shut up. This is not the time to announce the sanctity of your unmodified immune system. You’re the Salem witch du jour, the baconburger dragon that every two-bit junior science writer is dreaming of. Time for a low profile, the old D & L. How about that European vacation you’ve been talking about all these years?

You’re about to get the rudest awakening to the state of the union you’ve been paying taxes in all these years. Your survival instinct not to allow your children’s bloodstream to be the battle ground for one of the most corrupt political battles ever – your right to medical freedom, to decide which medicines you may choose – all that is in play right now.

You’re no longer a person, or a citizen with rights, etc – none of that. Suddenly you’re just dinner. Red meat for a salivating, amoral, goosestepping, lowborn media mob. Your new script is “Oh yes, I’ve had all the vaccines I need.”

No interviews. They’ll never air your views and the simplest science is miles over their head. They’re just looking for that one weird sentence of yours that makes no sense, that they can turn into a looped soundbyte and make you look like a dangerous imbecile.

Ask Jack Wolfson. Or Chris Christie.

CALIFORNIA – THE END OF AMERICA

Even for the vaccinated in California who have never needed exemption forms, now may be the time to sign them – before they disappear forever into the misty archive of faded rights and lost personal freedom that we have carelessly bartered away for the illusion of security.

Sign the exemption form? Me? Are you nuts? Why would I do that?

Because when the misbegotten, spineless lemmings in Sacramento pass the new bill to abolish exemptions, they’ll have to leave the exemption door open just a crack in order to prevent massive liability claims for vaccine injuries. And that crack will be medical exemptions.

The only way you’ll be able to opt out of vaccines in California then will be to get a medical doctor to sign an exemption. The difference will be that now, he won’t have to do it just because you have a philosophical objection. No, now the child will need a clinically verifiable allergy to vaccines to be exempt.

Every exemption the MD signs will be one less patient who has to pay for an office visit. How motivated are they going to be for that?

Beginning to see how this works?

But why would the vaccinated need exemptions? Wait for it — because even if you believe in vaccines, having an exemption form will allow you to pick and choose the vaccines you want. With 69 mandated vaccines and climbing, what do you think the future will bring?

Unlimited vaccines into your child’s body, mandated no longer by science but by a politically motivated gang of bought-and-paid-for legislators, who always vote the way they’re told. The party line.

It will take some time for the new bill to pass through and become law, so now is probably the last chance to act. Whether or not you have faith in vaccines.

List of doctors who MAY sign exemptions:

DEBATE CHALLENGE

For years, I have had no takers to my standing challenge to any and all professionals for a debate on the true science of vaccines – a debate in the classical collegiate forensics format.

Why are they so afraid? Because in a debate, with equal time, the true science of vaccines would be aired in a public format. Full disclosure – that’s not the way they do business – it’s their worst nightmare.

That’s why you’ve never seen a debate on vaccine issues. E.L. Bernays traditional media must control both sides of any argument, so that the result is there is only one opinion. Theirs. To have the indolent, unlettered public exposed to the raw factual science of vaccine safety and toxicity, according to the manufacturers themselves – no, no we can’t have that.

But there it is – the challenge still stands. Any of you Pans or Offits or Guptas feeling frisky? Not saying you’re chicken, but you sure seem to have henhouse ways.

Anyone who has ever read our vaccine textbook knows that I am not an anti-vaccine activist. All the research on our website is in favor of any vaccines that have been proven to be absolutely safe, effective, and necessary by legitimate, verifiable third party science – research that is wholly unconnected with vaccine manufacturers and their satellites.

This short article is too much for the majority of people to read, let alone digest. The lie repeated often enough becomes the truth, thank you Mr Goebbels.

We are in a position where the popular opinion created by this nonexistent “epidemic” of vaccine-caused measles cases is being brokered into a new and unprecedented level of insanity and social irresponsibility.

The failures of modern medicine are apparent all around us. We have the worst overall health of any industrialized nation. Our children receive twice the number of vaccines than any other country on earth. Those are scientific facts, and they are undisputed.

This new wave of greed and mind-control, ushered in by an irresponsible media representing an amoral drug cartel with unlimited resources – has the potential to weaken the genome of the American people to its lowest level in the country’s history.

Measles vaccine does not prevent measles. It causes it.

Mandatory drugs and vaccines…Really? What’s next – mandatory obesity?

—————————copyright MMXV thedoctorwithin ———————————

______________________________________________________________

Vaccination Is Not Immunization

This is not a reprint of the third edition, which was recently sold out, but rather a complete re-write.

Here are some of the topics covered in the new edition:

– Why the 2014 Ebola hype came and went so quickly
– what happens when the federal government takes over vaccine research from actual scientists
– why the new Ebola ‘victims’ were never tested
– the new US schedule of 69 vaccines for kids
– evidence why 54% of US children already have a chronic disease
– reservoirs for disease: the vaccinated or the unvaccinated?
– motivated vaccine investors: Bill Gates, Mark Zuckerberg
– “fast-tracked”- the new synonym for untested
– the science behind individual vaccines
– much more

210 pages, almost 300 references. Every fact verified, every statistic sourced. Open challenge for debate.

You want to vaccinate your children? Fine. But don’t you think it’s important to find out exactly what vaccines are, according to the scientists who create them, instead of the sales force who delivers them?

Vaccination Is Not Immunization – now in 6 languages

The most reliable vaccine resource for parents about to make the most important decision of the child’s life.

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“The great enemy of the truth is very often not the lie — deliberate, contrived and dishonest, but the myth, persistent, persuasive, and unrealistic. Belief in myths allows the comfort of opinion without the discomfort of thought.”
~ John F. Kennedy

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Excerpt from Vaccination Is Not Immunization, fourth edition:

“MEASLES

Before we begin our discussion of Autism, let us take a quick look at the controversial MMR vaccine.

Measles is a mild, self-limiting, immune-building viral disease of childhood. Symptoms are red spots on the skin and mouth, fever, and fatigue. Commonly resolves in a week.

Most of those who grew up in the 1950s remember getting measles. Not a big deal. And they got lifetime immunity in the bargain. Natural immunity. (Merck, p 1098) [224]

Looking at the Figure 2 above, we see the disease almost completely disappeared by itself before mass vaccinations became popular in the 1970s.

Measles vaccine was part of the MMR (measles-mumps-rubella) vaccine package developed in the early 1970s. Once again, it wouldn’t be so bad if the vaccine were simply unnecessary. But an entire array of side effects can result from the MMR vaccine:

loss of muscle control
meningitis
seizures
mental retardation
Reyes Syndrome
diabetes
paralysis
anaphylactic shock
MS
Guillain-Barre
blood clot
encephalitis

But the reason the MMR vaccine was sold to the public in the first place was to protect against encephalitis. Now here it’s listed as a side effect of the vaccine?

Measles itself doesn’t cause all these illnesses. Even pediatricians know that the vaccine contains a slow virus that can hide in tissues for years, and then manifest later in life. This is why so many doctors in Los Angeles refused to use the MMR vaccine on their own children. – (Mendelsohn, p 237,238) [210])

A 1996 report stated that the measles vaccine “produces immune suppression which contributes to an increased susceptibility to other infections.” – Clinical Immunology and Pathology, (Auwerter) [172]

Let me get this right. Not only does the measles vaccine not prevent measles; it also increases the chances of getting other infections? Looks like the vaccine’s worse than the disease.

And we have mandated such a vaccine for the general population based on undocumented claims of possible encephalitis?

With measles specifically, the absence of antibodies after vaccination has been known for decades: “Antibody production is therefore not necessary either for recovery from or for the development of immunity to measles.” – Nobel laureate, Sir MacFarlane Burnet [176]

DOES IT WORK?

Let’s trace the vaccine’s effectiveness for preventing measles.

By 1978, half the cases of measles were found in vaccinated children. And the W.H.O. stated that those vaccinated have a 15 times greater chance of catching measles than those not vaccinated! ([210], p 238)

Between 1983 and 1989, incidence of measles increased 10-fold.

In the next year, incidence increased another 50 percent! 1990 saw 27,000 cases and 100 deaths reported in the U.S. [195] (p 511)

Furthermore the CDC itself reports measles outbreaks in populations with 100% vaccination rates!

Their explanation: …the apparent paradox is that measles…becomes a disease of immunized persons. (MMWR, Oct 1984) [239]

What about the value of childhood measles as an immune-building experience? From Viera Scheibner: [230] “It is well known that measles is an important milestone in the maturing process of children. Why would anybody want to delay the maturation process of children and their immune systems?”

The real horror about the measles vaccine, however, didn’t explode into public awareness till the House of Representatives hearings on autism, convened by Dan Burton on 6 April 2000. [169] Legit research done in England and Ireland began to show the measles vaccine as one of the two most likely causes of autism. [287],”

“Can you explain why a little creature, who can’t even understand what’s done to her, should beat her little aching heart with her tiny fist in the dark and the cold, and weep her meek, unresentful tears to God to protect her? Do you understand why this infamy is permitted? Without it, man could not have existed on earth, for he could not have known good and evil. Why should he know that diabolical good and evil when it costs so much? Why, the whole world of knowledge is not worth that child’s prayer to God! I say nothing of the sufferings of grown-up people – they have eaten the apple, damn them, and the devil take them all! But these little ones!”
– F. Dostoyevski

“The most provocative, well-researched, blood-boiling text EVER written on vaccines… Dr Tim’s style mixing pure science and his relentless wit make this one of my FAVORITE reads of all time. Read this book and you will want to start a revolution.”
– Dr Bill DeMoss, Newport Beach

“This history of the vaccination industry is vastly more thorough than that taught in medical schools and decisively more balanced.”
– David Ayoub, MD

“The only book more important than this one is the Bible.”
– Dr Tim Young

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Vaccination Is Not Immunization

(915) 307-1055

Order Book >>

Personal note: I am not hawking this book and I don’t have any ties to The Doctor Within or to any affiliates of The Dotor Within or to the publishing house which published this book. The only reason I included it here with this article is that I thought it might be a valuable resource for people wanting verifiable scientific information on vaccines. I found this article at the website TheDoctorWithin.com . All copyrights belong to them. This is mainly an op ed piece, but it does have some good points and the links provide good information as well. 

Polish Study of Neurologic Adverse Events Following Vaccination

Polish Study of Neurologic Adverse Events Following Vaccination

Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 129 Neurologic adverse events following vaccination Sienkiewicz D.*, Kułak W., Okurowska-Zawada B., Paszko-Patej G. Department of Pediatric Rehabilitation of the Medical University of Bialystok, Poland

ABSTRACT __________________________________________________________________________________________

The present review summarizes data on neurological adverse events following vaccination in the relation to intensity, time of onset, taking into account the immunological and non-immunological mechanisms. The authors described the physiological development of the immune system and the possible immune system responses following vaccination. Toxic property of thimerosal – a mercury-containing preservative used in some vaccines was presented. The neurological complications after vaccination were described. The role of vaccination in the natural course of infectious diseases and the current immunizations schedule in Poland was discussed.

Key words: vaccination, neurologic adverse events following vaccination, immunization schedules __________________________________________________________________________________________ *Corresponding author: Department of Pediatric Rehabilitation Medical University of Białystok 17 Waszyngtona str, 15-836 Białystok Poland E-mail: sdorota11@op.pl (Dorota Sienkiewicz) Received: 29.01.2012 Accepted: 22.02.2012 Progress in Health Sciences Vol. 2(1) 2012·pp 129-141. © Medical University of Bialystok, PolandProg Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 130

INTRODUCTION

Adverse reactions In developed countries, the schedules of mandatory and recommended vaccination for children contain more and more components with a specific emphasis on the co-administration of multiple antigens in combined form. This direction on the one hand provides many benefits and on the other carries an increased risk of side effects, the immunopathogenesis of which is not fully explained in many cases [1]. An adverse event following immunization (AEFI) is an undesirable side effect occurring after the administration of a vaccine [2]. It is a temporary, local or general reaction of the organism to an administered vaccine. A postvaccinal complication (PC) is associated with an excessive or pathological reaction with the characteristics of postvaccinal disease, which in extreme cases can lead to permanent damage, threat to life or even death [3]. Complications affecting the nervous system raise the most controversy; the more so, as the children subjected to vaccination are healthy.

In annex no. 1 to the Ordinance of the Minister of Health of 23rd December 2002 on adverse events following vaccination (Journal of Law from 31/12/2002, no. 241, item 2097, as amended. Journal of Law from 2005, no. 232, item 1973), the following categories of AEFI are presented [4].

1) Local reactions, including:

  • a) local reactions after the BCG vaccine,
  • b) swelling,
  • c) lymphadenopathy,
  • d) abscess at the injection site;

2) Postvaccinal adverse events of the central nervous system:

  • a) encephalopathy,
  • b) febrile convulsions,
  • c) non-febrile convulsions,
  • d) paralytic poliomyelitis caused by vaccine virus,
  • e) encephalitis,
  • f) meningitis,
  • g) Guillain – Barre syndrome;

3) Other adverse events following immunization:

  • a) joint pain,
  • b) hypotonic-hyporesponsive episode
  • c) fever above 39⁰C
  • d) thrombocytopenia,
  • e) continuous inconsolable crying.

Other classifications of postvaccinal reactions can be found in the literature, some of which put an emphasis on the neurological symptoms, while others emphasize the immunological mechanisms.

Byers et al. describing neurological complications, have included as “minor” – mild or severe postvaccinal reactions, occurring up to 48 hours after injection and disappearing without leaving permanent sequelae, the following:

  • prolonged crying,
  • restlessness and hyperactivity,
  • apathy with increased sleepiness,
  • high body temperature,
  • a temporary mild increase in intracranial pressure manifested by a throbbing crown of the head,
  • “cerebral cry” (sometimes included among “major” complications) [5-7].

Among the “major” neurological complications, usually manifesting more than 48 hours after vaccination and which might be the cause of permanent damage to the central nervous system (CNS), the following are listed:

  • seizures – especially if there is no increase in body temperature,
  • hypotonic-hyporesponsive episodes,
  • postvaccinal encephalitis,
  • postvaccinal encephalopathy [6, 8-11]
  • and autism [10, 12-14].

Konior and Strózik [7] have proposed their own classification of postvaccinal reactions taking into account the contribution of the immune system in the vaccinated children. They divided the adverse events into two groups:

1. related to the immune system – patients with immunodeficiencies (mainly cellular) and atopic patients with hypersensitivity to certain vaccine components

2. unrelated to the immune system – patients whose postvaccinal reactions may be related to the toxic effects of the vaccine components or may result from the vaccine virus turning virulent, resulting in complete or abortive symptoms of the disease.

Another classification of adverse events following vaccination distinguishes:

Local postvaccinal reactions (redness, swelling, pain at the injection site) occurring particularly often after the administration of live vaccines (10.8% -15.5% of reports) [15]

 Generalized postvaccinal reactions (fever, malaise, muscle pain, joint pain, headaches, flu-like symptoms, local lymphadenopathy, allergic reactions) – usually disappear spontaneously within 3 days of vaccination, do not require treatment [16].

 Early postvaccinal complications – anaphylactic reaction, described in one in about 1 million of vaccinated individuals, occurs most often after immunization against typhoid, tetanus, pertussis, measles, mumps, rubella [16].

 Late and long-term complications – determined by different immunological mechanisms, occur most often after the administration of preparations containing live micro-organisms (e.g., flaccid paralysis after an oral poliovirus vaccine OPV – 10 individuals annually per 1 million people vaccinated) [16].

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Neurologic adverse events vaccination 131

Reports in many Polish and foreign medical journals lead us to conclude that postvaccinal complications among children can be observed in sporadic cases and that they are disproportionate to the benefits of vaccination in the elimination of dangerous diseases in childhood. This article focuses on several aspects related to overall immunization, including: the physiological development of the immune system, the possible immune system responses following vaccination, the site of vaccination in the natural course of infectious diseases and the current immunization schedule in Poland compared with other countries. The immune system in terms of vaccination

Physiology

Immune system functioning in neonates is characterized by complex mechanisms to adapt to the changed conditions of postnatal life. In infancy and early childhood, the individual components of specific and nonspecific immunity gradually develop and mature [17]. The humoral immunity of neonates is acquired and is associated with active transport of maternal immunoglobulin G through the placenta (starting from the end of the first trimester of pregnancy) mainly in the last 5-6 weeks of pregnancy. A neonate’s humoral response is therefore a state of physiological dysimmunoglobulinemia, i.e. it has an average concentration of its own IgG, minimal or low concentrations of IgA, IgM, IgE, IgD [13, 14]. The level of maternal IgG gradually decreases, while the level of the child’s IgG increases reaching approximately 60% of the adult level after 12 months. In the 2-3 month of life, an intersection of curves takes place – the declining curve of maternal IgG concentration and the increasing curve of infant IgG concentration (graph). The infant’s IgG level is the lowest then [18].

Levels of antibodies in the blood serum of the fetus, neonate and infant [18] From a physiological point of view, according to Jakóbisiak’s [18] classification, the group of secondary immunodeficiency disorders includes conditions such as pregnancy and conditions associated with age (neonates, the elderly). Premature babies are a specific group, whose shortened period of maternal IgG influx leads to compromised anti-infective immunity. On the other hand, according to the author, on account of the existing maternal antibodies, vaccination against certain microorganisms administered shortly after birth does not lead to long-lasting immunity. It should be emphasized that the immune system reaches full immunoregulatory and defensive maturity at about 3 years of age [19]. It is well established that early-life immune responses are weaker and of shorter duration than elicited in immunologically mature hosts. Consequently, vaccine efficacy in early infancy (particularly in the first 6 months of age) is limited [20]. Thus, in oder to provoke and sustain an adequate B-cell immune response in a neonate, strong immune adjuvants and repeated closely spaced booster doses are needed [21]. The problem with this approach is two-fold. First, experimental evidence clearly shows, that simultaneous administration of as little as two to three immune adjuvants, or repeated stimulation of the immune system by the same antigen can overcome genetic resistance to autoimmunity [22]. Second,while it is generally accepted that potency and toxicity of immune adjuvants must be adequately balanced so that the necessary immune stimulation is achived with minimal side effects, in practical terms, such a balance is very difficult to achieve. This is because the same adjuvantedmediated mrchanisms which drive to the immunestimulatory effects of vaccines have the capacity to provoke a variety of adverse reactions [23, 24] Vaccinations and immune response A vaccine is defined as a biological preparation containing antigen(s) of microorganisms that cause specific stimulation of the immune response after administration which protects against infection by this microorganism, with safety precautions taken during administration [18, 25].

A vaccine may contain:

  • 1. Microorganism antigens – bacterial or viral (live-attenuated, dead), isolated antigens – proteins, polysaccharides, DNA and anatoxins (diphtheria, tetanus) with retained immunegenicity but devoid of pathogenic properties,
  • 2. Suspension: water, physiological saline, substrate protein, e.g. egg white, gelatin,
  • 3. Preservatives: thiomerosal (mercury), antibiotics, phenol,
  • 4. Adjuvants, the aim of which is to enhance the immunogenicity of the vaccine – aluminum hydroxide or aluminum phosphate are the most commonly used.

Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 132

According to the literature [18], it is believed that vaccines containing live microorganisms are among the most effective means of inducing immunity against infectious disease. Attenuated microorganisms (viruses, BCG mycobacteria) retain the ability to replicate in host cells, which stimulates cytotoxic T lymphocytes (Tc, CD8 +) that destroy cells infected by them. The way of impact of isolated antigens or antigens derived from whole inactivated microorganisms is different. In this case, a stimulation of the auxiliary Th (CD4+) lymphocyte response takes place. Th lymphocytes contain two distinct – in functional terms – subpopulations: Th1 and Th2. According to Jakóbisiak – with some simplification – it can be assumed that the Th1 lymphocytes perform auxiliary functions in cell-type response and Th2 in humoral response [18]. The mechanism of immune response to various types of vaccine antigens, especially to antigens in multicomponent vaccines, is not fully understood and researched.

The vaccination-stimulated Th2 pathway responsible for the production of antibodies, the pathway which predominates in neonates and infants, in the absence of an adequate balance of Th1 response may lead to the development of allergic reactions [25]. This is symptomatic of the fact that allergic diseases are often referred to as “an epidemic of the XXI century” [26, 27]. As stated in the “European Allergy White Paper”, the clinical symptoms of allergy are present in 35% of the population of developed countries, and according to the ISAAC (The International Study of Asthma and Allergies in Childhood) as many as 40%. Allergy is one of the major health problems on par with AIDS, cancer, cardiovascular diseases, injuries and accidents [28 – 30]. According to other authors, a restriction of the natural environmental infections stimulating Th1 response as well as change of their natural course resulting from mass immunization, an increase in general hygiene and widespread use of antibiotics (“Hygiene Theory”) inhibiting and delaying the adjustment of Th2/Th1 could theoretically also contribute to the growth of the risk of allergic diseases [31, 32]. A confirmation of this thesis was the study of Swiss children from anthroposoic backgrounds, in which significantly less atopy was observed than in children from other backgrounds. In this group, a positive correlation of diseases with the MMR vaccination was found [33]. In addition, in a series of papers, Silverberg et al. have shown that wild type varicella zoster virus infection (WTVZV), but not varicella vaccine (VV), protects against asthma and atopic dermatitis (AD) in young children [34, 35]. The protective effect of WTVZV was attributed to its beneficial effect on stimulating Th1-primed immune responses and suppressing allergy-promoting Th2 responses. According to Silverberg et al. [34], ―The introduction of widespread varicella vaccination and resultant decline of WTVZV in the United States may be a contributing factor in the increased prevalence of AD [atopic dermatitis] over the past few decades.‖ Notably, other than not providing an effective stimulus for proper immune system development, recent research has shown that vaccines are actually capable of disrupting it. For example, annual vaccination against influenza has been shown to hamper the development of virusspecific CD8+ T-cell immunity in children [36] From the above observations it is clear that the proper functioning of the immune system involves a delicate balance between the two arms of the immune equilibrium (Th1/Th2), and its tilt to either side can be harmful for the body [30]. Furthermore, it appears that the necessary Th1/Th2 balance is better provided by natural challenges (i.e., in a form of relatively benign childhood diseases such as chickenpox and mumps) rather than vaccination. Recent research by Singh of the International Institute for Brain Research in the USA confirm the veracity of this statement. In the study, serum and cerebrospinal fluid (CSF) were analyzed in terms of viral and autoimmune markers in Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 133 patients with autism compared with a group of healthy children – both groups were vaccinated with MMR (measles, mumps, rubella vaccine) [37]. This is the first of this type of research examining a positive correlation between viral factors (viral serology) and autoimmune factors (brain autoantibodies). It was found that higher levels of measles antibodies were accompanied by Myelin Basic Protein (MBP) autoantibodies in children with autism (Figure.3). A similar serology was found in CSF. Fig. 3. Correlations between MMR antibodies and MBP autoantibodies in autistic and healthy children. (Source: [37] Singh VK. Phenotypic expression of autoimmune autistic disorder (AAD): A major subset of autism. Annals of Clinical Psychiatry, 2009, 21, 3,148-161; with permission: Healthy Impressions) The results in Table 1 show a comparative study of antibodies against other viral pathogens in the studied population of children which confirmed the pathogenic role of the measles strain.

Table 1. Blood serum levels of antiviral antibodies in healthy and autistic children Virus antibody (units)

Measle s Mu mps Rub ella HH V-6 CMV EBV EA EBN A VC A

  • Normal children 3.3±0. 1 2.5± 0.2 3.2± 0.2 1.6± 0.6 0.28 ±0.4 0.5±0 .04 1.2 ±0.2 1.8± 0.3 (n=32) (n= 30) (n=4 5) (n= 37) (n=3 0) (n=4 4) (n=4 4) (n= 44)
  • Autistic children 4.2±0. 1* 2.6± 0.3 3.3 ±0.1 2.2± 5.3 0.23+ 0.3 0.6 ±0.04 0.9± 0.2 1.4± 0.2 (n=87) (n= 32) (n=7 4) (n= 45) (n=3 0) (n=4 4) (n=4 4) (n= 44) p value .003* .76 .98 .5 .37 .76 .21 .15

(Source: [37] Singh VK. Phenotypic expression of autoimmune autistic disorder (AAD): A major subset of autism. Annals of Clinical Psychiatry, 2009, 21, 3,148-161; with permission: Healthy Impressions)

CMV: cytornegalovirus; EA: early antigen; EBNA: Epstein-Barr nuclear antigen; EBV: Epstein-Barr virus; HHV-6: human herpesvirus-6; VCA: viral capsid antigen; *Student t test was used to evaluate significance at a p value < 0.05 Significantly elevated levels of cytokines – IL-2, IL-12, IFN-γ (factors triggering autoimmune response) – and acute phase proteins were also found in patients [37].

According to the authors of this study, subtle changes in the child’s developing brain caused by an autoimmune reaction, changes in the myelin sheath, may ultimately lead to impairment Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 134 of higher brain functions such as speech, communication, social interaction, as well as other neurological symptoms occurring in children with autism. In this study, the measles viruses were researched, but under the immunization program children also receive vaccinations with simultaneous administration of several viral components. What then occurs in the brain of a child? Presently, there are no studies in this area.

In an earlier study concerning postvaccinal adverse events of the immune system, Mannhalter et al. [38] presented an analysis of T lymphocyte (Th1/Th2) subpopulations in healthy adults before and after the administration of a vaccine containing the tetanus toxin. The result was a decrease in the Th1/Th2 ratio after vaccination, with maximum intensity 3 to 14 days after injection. These reports present a picture of neuroimmune disorders which may be the result of vaccinations carried out on an increasingly wider scale. A clear answer to this hypothesis would require both large-scale epidemiological studies as well as in-depth laboratory research. In Poland, multi-antigen combination vaccines are commonly administered at full cost with parental consent. Most often children are immunized at the same time with: diphtheria and tetanus toxoid, acellular pertussis antigen, polio and H.influenzae (Infanrix-IPV+Hib, Pentaxim vaccines) or with an additional antigen of hepatitis B virus (Infanrix hexa vaccine). These vaccinations are repeated from the second month of life 3 times every 6-8 weeks. The recommended vaccinations against rotavirus and pneumococcal (2-3 doses) are also proposed to children under 6 months of age. Together with the tuberculosis and hepatitis B vaccinations administered in the first 24h of life, an infant receives 24-26 doses of xenogenic antigens. According to Tsumiyama et al. [39] systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host’s immune ‘system’ by repeated immunization with antigen. Indeed, in adults multiple vaccinations have been associated with a variety of autoimmune phenolmena [40 – 42], yet children are regularly exposed to a much higher burden of vaccines than adults under the assumption that such exposures are safe [43] . Vaccinations as an important “training” for the immune system lower its threshold of defense responses, which is a measure to prevent the development of infectious diseases. However, a question arises: how will the not fully mature, still developing immune system of a healthy child and the still forming central nervous system respond to such intense stimulation? Is it able to correctly respond with the same protective effect to so many different stimuli? Do the multi-antigen vaccine side effects change compared to the previously used vaccinations and how? Thus far, these questions lack clear answers. Nonetheless, it is important to emphasize that a burgeoning body of evidence shows that immune molecules play integral roles in CNS development, affecting processes such as neurogenesis, neuronal migration, axon guidance, synaptic connectivity and synaptic plasticity [44 – 46]. Despite the dogma that peripheral immune responses do not affect CNS function, substantial evidence points exactly to the contrary [44, 47, 48]. Thus, it is not reasonable to assume that manipulation of the immune system through an increasing number of vaccinations during critical periods of brain development will not result in adverse neurodevelopmental outcomes [43, 49] Neurological symptoms following vaccination

In recent years, attention has been brought to the mercury contained in vaccines as a component with toxic and allergic properties. The mercury compound is found in organic combinations in the form of sodium salt – thimerosal (sodium ethylmercuriothiosalicylate, merthiolate). The incidence of allergy to this compound is variously estimated from 13% in the Netherlands to 21% in Austria. Vaccinations are a primary cause of the initial allergic reactions to thimerosal [50]. Mercury’s neurotoxicity (accumulation in the brain), cardiotoxicity, hepatotoxicity, nephrotoxicity, immunotoxicity, and carcinogenicity are mentioned as its toxic activity. It causes, among others, developmental disorders in children and neurodegenerative diseases in adults [7]. According to researchers [51, 52], a manifold incidence increase of psychoneurological diseases such as autism, ADHD, mental retardation, epilepsy and others have been observed all over the world over the past twenty years. As stated, from the 1990s new vaccines for infants containing thimerosal began to be used in America. In the DTP, Hib and Hep B vaccines, children received a dose of 62.5 ug of mercury, which is 125-fold more than the dose considered safe (0.1ug/kg/day). These reports were the reason that Scandinavian countries already prohibited the use of mercury in 1990 [53]. In 2005, a paper was published which describes the sudden death (SUD – Sudden Unexpected Death) of 19 infants within a few hours/days after vaccination with two hexavalent vaccines (DTP-Hib-HepB-IPV). The healthy prior to vaccination children died as a result of postvaccinal cerebral and lung edema and heart attacks. As the authors conclude, despite the lack of direct evidence for a causal relationship of the described SUDs with vaccination, it is a signal that brings to attention the need to monitor the course of vaccination and its complications [54].Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 135

In another study from 2004, Geier et al. [12] confirmed through epidemiological research the direct relationship between increasing doses of thimerosal and the incidence of autism in children in the US from the late 1980s through the mid- 1990s. In addition, there was a potential correlation between the number of primary pediatric measlescontaining vaccines (MMR) administered and the prevalence of autism during the 1980s. Geier et al. [12] also found a statistically significant odds ratios for the development of autism following increasing doses of mercury from thimerosal-containing vaccines (birth cohorts: 1985 and 1990-1995) in comparison to a baseline measurement (birth cohort: 1984). The contribution of thimerosal from childhood vaccines (>50% effect) was greater than that of the MMR vaccine on the prevalence of autism observed in the study. In Poland, according to the documents “Characteristics of Pharmaceuticals”, there are currently several permitted vaccines with significant thimerosal (THIM) content. These are: Euvax (Hepatitis B, LG Life Sciences, Korean manufacture) – 0.01% THIM-50μg/dose, DT (Biomed, Krakow) – 50μg/dose, Td (Biomed, Krakow) – 50μg/dose, DTP (Biomed, Krakow) – 50μg/dose, D,d (Biomed, Krakow) – 50μg/dose, TT (Biomed, Krakow) – 50μg/dose [4, 55]. The frequency of observed reactions and complications depend on the general condition, especially neurological, of the child, the age, immunological resistance status as well as family and genetic load. In the literature, neurological symptoms are usually connected with the pertussis component of the vaccines, including: cerebral cry, according to Cody, occurs in 1:1000 of vaccinated subjects; seizures – mild, feverish – triggered by the pertussis endotoxin, in 10% of vaccinated subjects the convulsions occur without elevated body temperature, and severe seizures occur according to Waller et al. in 1 in 106,000 children [25]. In serious complications, such as encephalitis (about 2.9/10,000,00 of those vaccinated with DTP), encephalopathy (1:140,000 – 1:300,000 of the vaccinated), which may result in mental retardation, recurrent seizures, epilepsy – particularly myoclonic and Lennox-Gastaut Syndrome, changes in the central nervous system comparable to those which occur in the course of meningitis and encephalitis were reported. In the early stages, perivascular lymphocytic infiltration and demyelination outbreaks were observed, then myelin atrophy with intact neuron axial fiber, degenerated microglia and macrophage cells. Some experimental studies suggest the pertussis toxin, which through the membrane receptors causes inhibitory neurotransmitter dysfunction and induces activity of excitatory neurotransmitters [56, 57]. In 2010, a case of a 6-month-old previously healthy boy admitted to hospital on day 6 after vaccination with DTwP (whole cell) was described. The child was in a coma, hypotonia, with focal clonic seizures. MRI of the central nervous system using proton spectroscopy revealed acute necrotizing encephalopathy [58]. Previously, epileptic seizures in children with asymptomatic CMV infection which occurred after vaccination with DTwP and OPV had also been described. In the case of hepatitis C virus (HCV) infection, DTaP (acellular) and IPV (inactivated) vaccinations are recommended [59]. As stated in the Polish literature, acellular vaccines are much better tolerated than whole cell – the risk of fever after the first dose is reduced by over 99%, the risk of hypotonic-hyporesponsive episodes by 56%, similar to seizures, and the risk of inconsolable crying after the first dose is reduced by 87% [4]. According to the current vaccination schedule in Poland, infants receive the first three doses of DTwP in the first 6-8 weeks of life every 6-8 weeks, the 4th dose in the 16th-18th month of life, and a DTaP booster at 6 years of age. Given the often reported neurological complications after whole-cell pertussis (DTwP, DTP) vaccine, most developed countries – European and the US – have introduced changes in their immunization schedules and the safer acellular (DTaP) vaccines are administered to children. Of these countries, the only exceptions are: Bulgaria, Malta and Poland. In Poland, the safe vaccine is paid in full.

Other neurological complications associated with the administered vaccination are listed, among others, as follows:

  • multiple sclerosis after hepatitis B vaccine [60],
  • Guillain-Barre syndrome – after vaccination against influenza, hepatitis, meningitis C, polio and HPV vaccines [61-65],
  • transverse myelitis as a result of vaccination against cholera, typhoid, polio, and influenza,
  • flaccid paralysis, meningitis, encephalitis, convulsions and facial palsy after live polio vaccine [65, 66],
  • rapid progression of retinopathy in premature infants after BCG vaccination [67].

Monitoring In the case of AEFI, the obligation of notification was described in article 21 of the Preventing and fighting infections and infectious diseases in humans Act. According to the Act, a physician who recognizes or suspects the occurrence of AEFI is required, within 24 hours after concluding the suspicion, to notify the State Sanitary Inspector of the suspected case [3]. In order for that to be possible, the child’s guardian must also be accurately informed about the adverse symptoms following vaccination that may occur, then report the problem to the doctor or nurse who will take further steps.

There was an attempt to trace the actual scale of the adverse events following vaccination reported by nurses and doctors. Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 136  The monitoring system was introduced in Poland in 1996 and is based on the WHO recommendations. In the Zieliński study, the number of AEFI reported in 1996-2000 from different provinces was analyzed and clear differences regarding the frequency of recorded entries were found. As the authors write, “they met astonishing examples of ignorance of the medical staff, including specialists, in their duty to report the AEFI” in their epidemiological practice [68]. On the other hand, there is no real possibility of laboratory tests to confirm a causal relationship between the clinical picture and the used vaccine. For example, only a few research laboratories in Poland, of the highest reference level, posses the microbiological methods for distinguishing mycobacteria from the BCG vaccine from other species of the Mycobacterium tuberculosis strain [69]. There are also no reports in the literature (except those listed above) of research work in immunology in the context of reactions following vaccination. It should also be noted that in more developed countries, there is little incentive for doing appropriate follow-up and laboratory tests on individuals who suffered serious adverse reactions following vaccinations [70]. The reason for such oversight is likely due to the fact that historically, vaccines have not been viewed as inherently toxic by the regulatory agencies [68] The resulting lack of evidence of causality between vaccinations and serious adverse outcomes has thus been filled with an assumption that vaccines are safe [71]. Natural history of infectious diseases/ immunizations Based on statistics from the Federal Statistics Office in Wiesbaden, Buchwald published a paper containing long-term observations of morbidity and mortality from infectious diseases. It is interesting that in recent decades a decrease of infectious diseases was generally reported, which took place before the introduction of inoculations against these diseases. According to a 2002 report from Lancet Infectious Diseases [72] ―the weight of evidence collectively suggests that personal and environmental hygiene reduces the spread of infection‖ and ―Thus results from this review demonstrate that there is a continued, measurable, positive effect of personal and community hygiene on infectious‖. The same report showed that the crude death rate from infectious diseases decreased to nearly negligible levels long before introduction of universal vaccination practices. Currently, the developed countries introduce increasingly complex vaccination schedules. Forty years ago, children were immunized against five diseases (diphtheria, tetanus, pertussis, polio, smallpox), today this number has increased to eleven. At the same time, as mentioned previously, repeatedly administered multi-antigen vaccines are recommended. Doctors and researchers point to the worsening state of health of the child population since the 1960s, which coincided with increasingly introduced vaccinations. Allergic diseases, including asthma, autoimmune diseases, diabetes and many neurological dysfunctions – difficulty in learning, ADD (attention deficit disorder), ADHD (attention deficit hyperactivity disorder), seizures, and autism – are chronic conditions, to which attention has been brought [73]. Proposals for modification of the vaccination schedule European countries have different models of vaccination that have been modified in recent decades. In Scandinavian countries, which have the lowest infant mortality, vaccinations are voluntary and infants receive their first vaccination at 3 months of age. In the first year of life, they receive 9 recommended vaccinations, and at 18 months – MMR. The acellular pertussis vaccine (DTaP) is used, as well as IPV. BCG and Hepatitis B vaccines are administered to children from high risk groups. Similar vaccination schedules exist in other European countries, where the vaccination of neonates was abandoned and a ban on the use of thimerosal in vaccines was introduced [4, 74]. Note also that Scandinavian countries have the lowest rates of autism compared to other developed countries in which children are vaccinated much earlier and with greater number of vaccines [49]. Professor Majewska – a neurobiologist, Director of the Marie Curie Chairs Program at the Department of Pharmacology and Physiology of the Nervous System in Warsaw – together with pediatricians, drafted a proposal for changes to the vaccination program in Poland, which is based on an analysis of programs in other European Union countries. The propositions are as follows:

1. Eliminate thimerosal from all vaccines.

2. Discontinue the immunization of infants with the hepatitis B vaccine (vaccinate only newborns at high risk, i.e. of infected mothers).

3. Discontinue BCG vaccination of neonates (use only in regions where the percentage of TB patients is over 40 per 100 thousand).

4. Begin vaccination from 4 months old in the remaining group of children.

5. Discontinue the whole cell pertussis vaccine.

6. Give a maximum of three types of vaccines in one day.

7. Discontinue the administration of live virus vaccines or give them one at a time at safe intervals.

8. Make monovalent vaccines accessible.

9. Commitment of the doctor administering the vaccine to conduct a preliminary interview with the parents about allergies, asthma and other autoimmune diseases and postvaccinal complications in family members, allowing them to predict whether a given child may experience severe postvaccinal reactions. Such a child should have an individual, very careful vaccination program developed.

10. Monitor the health status of children after vaccination in order to notice life- or healththreatening conditions in time.

11. Create a national program for compulsory registration of postvaccinal complications and deaths. These data should be reported to the WHO and information about complications should be provided in the child’s health record book [51]. Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 138

CONCLUSIONS

Despite the assurances of the necessity and safety of vaccinations, there are more and more questions and doubts, which both physicians and parents are waiting to be clarified. This paper describes several aspects of the immunization program of children. It includes:

  • the physiological development of the immune system,
  • the immunization schedule adopted in Poland in comparison with other countries,
  • adverse reactions and complications following vaccination described in scientific publications,
  • the natural course of infectious diseases in conjunction with the vaccination programs implemented
  • and the problem of reporting adverse reactions following vaccination by medical personnel and parents.

The proposal for changes in vaccination in Poland cited at the end of this paper is, according to the authors, part of the answer to the concerns and doubts. A second part would be extensive neuroimmunological research confirming or excluding the relationship of vaccines with the reported adverse events (early, late/long-term) and chronic diseases whose upward trend has been observed in recent decades in children. It seems that it would be worthwhile to apply the precautionary principle – the ethical principle (from 1988) according to which if there is a probable, although poorly known, risk of adverse effects of new technology, it is better not to implement it rather than risk uncertain but potentially very harmful consequences.

ACKNOWLEDGMENTS

We are grateful to Mrs. Ursula HumienikDworakowska for the translation of this article.

Conflicts of interest

We declare that we have no conflicts of interest.

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