Ben Swann Reports on The CDC, Vaccines and Autism

Ben Swann Reports on The CDC, Vaccines and Autism

I encourage whoever reads this to check out this article and video on The CDC, Vaccines and Autism: Truth In Media: The CDC, Vaccines and Autism . I tried to post the video here, but I couldn’t find a direct link that was in the right format for WordPress.

Here is the article without the video along with the two links to the documents from Dr. Thompson who is the CDC whistleblower regarding the issue of the relation of the number of Autism cases of African American males under the age of 36 months who received the MMR (Measles, Mumps, Rubella) vaccine.

The debate over whether vaccines cause autism has become one of the most controversial disputes in this country. In this episode of Truth In Media, the focus is not on whether vaccines are responsible for autism. The issue at hand here is a study that was performed at the CDC and the question of whether the agency was complicit in a cover-up over a decade ago.

For nearly two years, Truth In Media has explored the allegations of Dr. William Thompson, a CDC scientist who came forward in 2014, hired a whistleblower attorney, and claimed that important data regarding a study on vaccines and autism was eliminated.
Thompson’s claims have led to a divide among Americans, with some believing that Thompson’s allegations are credible and should be investigated further, and others convinced that the documents Thompson handed over mean absolutely nothing. In December 2015, Ben Swann was the first journalist to obtain the documents from Congressman Bill Posey.

In this episode, Swann further examines not only Thompson’s claims, but also the documents related to the study, with the assistance of doctors, journalists, authors and former CDC specialists who joined Swann in discussing every document that was handed over.

Update, January 26, 2016, 2:16 p.m.: Due to a high volume of requests, the CDC documents given to Truth In Media are available below, split into two folders.

Click here to download Folder 1.

Click here to download Folder 2.

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Interview with Dr. Judy Mikovits Discussing the Role Vaccines Play In Autism and Numerous Other Diseases

Interview with Dr. Judy Mikovits Discussing the Role Vaccines Play In Autism and Numerous Other Diseases

Dr. Judy Mikovits Condemns Vaccines ‘Play Role In Autism’

dat

This is damning evidence against vaccines. Here is a description of the video from the interviewer, Candyce Estave.

This is is the most shocking & damming interview I have watched regarding vaccine injury. Released only 1 day ago it should go viral. Dr Judy Mikovits, PhD is a Biochemist, cellular and molecular biologist with over 30 years of scientific expertise. She has directed programs on HIV, cancer, epigenetics, and neuroimmune disease, with a focus on development of novel drug and diagnostic technologies. Dr. Mikovits holds a PhD in Biochemistry and Molecular Biology from GeorgeWashington University. Her dissertation was on HIV latency and mechanisms of immune activation in monocytes. Dr. Mikovits was a Postdoctoral Scholar in Molecular Virology at the Laboratory of Genomic Diversity, National Cancer Institute under Dr. David Derse.

Over the past 26 years, she has published 51 scientific papers in peer-reviewed journals, and worked as a government scientist for many years developing viruses and vaccinations. In 2011 when she made a horrifying discovery that was contaminating all vaccinations, she presented her data to government officials and was threatened & told to destroy all her data. When she did not she was jailed, her career systematically destroyed, and a gag order put in place for 4 years threatening that if she spoke out she would be thrown back in jail. That gag order has just lifted, and she’s dumped the government right in it! She speaks about how autism is associated with vaccines, also cancers, chronic fatigue syndrome, alzheimers, auto immune diseases, allergies and more. She discusses how the cocktail of vaccinations pumped into babies mutate to develop months and years down the track into new viruses, cancers and diseases, some they don’t even know about yet. She explains how the viruses injected through vaccines tear open our DNA and insert their own DNA to mutate our genetic makeup and be passed on generation after generation. She has been threatened with a suicide murder cover up, she doesn’t care, she wants it all exposed. The act of the Australian government making vaccinations mandatory is an act of genocide. If your jaw didn’t drop you obviously need to listen to it again. Via Jasmine Yuzwak

Interview with Dr. Judy Mikovits, PhD, 11/22/15 from Candyce Estave on Vimeo.

Bill Gates Faces Trial In India For Illegally Testing Tribal Children With Vaccines

Bill Gates Faces Trial In India For Illegally Testing Tribal Children With Vaccines

Bill Gates Faces Trial in India for Illegally Testing Tribal Children with Vaccines

Christina Sarich
BY CHRISTINA SARICH
POSTED ON OCTOBER 13, 2014

Bill Gates IndiaHave Bill Gates and his eugenicist foundation’s crimes against humanity finally caught up with him? If the Supreme Court of India has anything to say about it, he will face the ramifications of poisoning millions of Indian children with vaccines.

A recent report published by Health Impact News shows that a vaccine empire built on lies can only go on for so long. The reports states

“While fraud and corruption are revealed on almost a daily basis now in the vaccine industry, theU.S. mainstream media continues to largely ignore such storiesOutside the U.S., however, the vaccine empires are beginning to crumble, and English versions of the news in mainstream media outlets are available via the Internet.

One such country is India, where the Bill & Melinda Gates Foundation and their vaccine empire are under fire, including a pending lawsuit currently being investigated by the India Supreme Court.”

If you aren’t aware of the key players in the vaccine mayhem being driven into African countries, they are:

  • The Bill & Melinda Gates Foundation
  • PATH (Program for Appropriate Technology in Health, funded by the Gates’ foundation), and
  • GAVI (Global Alliance for Vaccines and Immunization, also funded by the Gates’ foundation)

All four of these organizations will now be expected to explain themselves due to a writ of petition originally submitted to the Supreme Court of India in 2012, by Kalpana Mehta, Nalini Bhanot, and Dr. Rukmini Rao, which has finally been heard by the courts.

The petitioners stated:

“BMGF, PATH and WHO were criminally negligent trialling the vaccines on a vulnerable, uneducated and under-informed population school administrators, students and their parents who were not provided informed consent or advised of potential adverse effects or required to be monitored post-vaccination.”

Furthermore, though absent from most mainstream U.S. media outlets, the Economic Times of India published their report in August 2014, stating that young tribal girls were tested with HPV vaccines. This involved not a handful of children, but 16,000 individuals in Andhra Pradesh, India, where they were given the Gardasil vaccine.

KP Narayana Kumar reported that within a month of receiving the vaccine, many of the children fell ill, and by 2010, five of them had died. Another two children were reported to have died in Vadodara, Gujarat, where another 14,000 tribal children were vaccinated with another brand of the HPV vaccine, Cervarix, manufactured by GlaxoSmitheKline (GSK), who incidentally, has been accused of dumping polio virus into a Belgium river.

Consent forms to administer the HPV vaccine were ‘illegally’ signed by wardens form youth hostels, showing that the Gates’ prey on the indigent without parents. For those who had parents, most were illiterate, and the true potential dangers of the vaccines were not explained to them.

SAMA, an organization in India which promotes women’s health discovered this insidiousness, and reported it, but only now will Gates and his cronies have to answer for their misdeeds. Approximately 120 girls reported epileptic seizures, severe stomach cramps, headaches, and mood swings, of those who did not die. Other girls receiving the Gardasil vaccine have experienced infertility.

The Economic Times further reported:

“The SAMA report also said there had been cases of early onset of menstruation following the vaccination, heavy bleeding and severe menstrual cramps among many students. The standing committee pulled up the relevant state governments for the shoddy investigation into these deaths.

It said it was disturbed to find that ‘all the seven deaths were summarily dismissed as unrelated to vaccinations without in-depth investigations …’ the speculative causes were suicides, accidental drowning in well (why not suicide?), malaria, viral infections, subarachnoid hemorrhage (without autopsy) etc.”

The Bill and Melinda Gates Foundation declared their little vaccine project a total success. I guess the Supreme Court of India will decide that now.

About Christina Sarich:
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Christina Sarich is a humanitarian and freelance writer helping you to Wake up Your Sleepy Little Head, and See the Big Picture. Her blog is Yoga for the New World. Her latest book is Pharma Sutra: Healing the Body And Mind Through the Art of Yoga.

Read more: http://naturalsociety.com/bill-gates-faces-trial-india-illegally-testing-tribal-children-vaccines/#ixzz3szagOEbn
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Vaccines: An Attorney’s Viewpoint

Vaccines: An Attorney’s Viewpoint

SOTN Editor’s Note:
The following exposé on vaccine safety and their inherent dangers is noteworthy because it is written by a Washington State attorney who really understands the profound legal ramifications. James Deal, J.D. wastes no time in completely deconstructing the many false assertions that are routinely presented by those government and corporate entities promoting  a super-vaccination agenda.

More importantly, Attorney Deal furnishes the American people with the substantive legal arguments which can serve as the basis for lawsuits against both the Pharmaceutical Industry and the U.S. Federal Government.  When considered in the aggregate, the implicit points of law delineated below constitute a legal foundation for a clear-cut criminal indictment.  Great harm is being inflicted on the children throughout the country by mandatory, state-sponsored vaccination programs.

No entity under the sun has the right or lawful authority to arrogate power unto itself to harm or injure, sicken or infect, paralyze or kill the people of this nation.  Not only is such conduct a serious breach of the social contract, it represents a profound violation of the public trust.  Vaccination programs therefore break the inviolable bond between the citizenry and the government.


You Cannot Generalize Pro or Con About All Vaccines

James Robert Deal J.D.

justice will prevail

The report below was recently sent to every representative and senator in the Washington legislature and to all the newspapers in Washington. Attorney James Deal believes that the personal or philosophical objection will be retained at the state level.

“They have all the money, but we have all the good ideas. If we persevere, we will succeed.”
~ James Robert Deal, J.D.

***

Anti-vaxxers oppose all vaccines. Pro-vaxxers favor all vaccines. No, it is not that simple. Pro-vaxxers admit that certain groups should not receive certain vaccines and that vaccine injury does happen, although it is “rare”.

Most so-called anti-vaxxers actually favor some vaccines but oppose others. Most oppose giving many vaccines all at one time. Most say they are only asking for safer vaccines.

Amid the name calling, there is a reasonable middle ground. Dr. Mark Geier, M.D., Ph.D., associated with Johns Hopkins and the National Institutes of Health, author of over a hundred peer reviewed journal articles, is a moderate we should pay attention to. (Go to YouTube and search for “Dr. Mark Geier Thimerosal”.)

Dr. Geier supports the measles-only vaccine, but he opposes the MMR, measles-mumps-rubella vaccine, because it has caused confirmed adverse reactions and death. Likewise, Dr. Gregory Poland, of the Mayo Clinic holds that the MMR is largely ineffective.

It is lazy language to say that vaccines are “safe and effective”, because that implies that all vaccines are safe and effective for all people. In fact, some vaccines have done great harm. If you doubt this, read the findings of the Vaccine Court, which has paid out around $3.0 billion to children for adverse reactions which admits were caused by vaccines. Go to www.uscfc.uscourts.gov/opinion-search and search for “measles-mumps-rubella” or “influenza”.  And read the package inserts that come with vaccine boxes. You may also read them online atwww.immunize.org/packageinserts

In Europe only the polio vaccine is mandatory. Dr. Geier supports vaccination against polio. However, he is adamantly opposed to flu vaccines. The flu vaccine given almost universally uses Thimerosal as a preservative. Each dose of Thimerosal contains 25 micrograms of ethyl mercury. Multiplied by Avogadro’s Number, 25 mcg = 75 quadrillion atoms of mercury.

25 x 10-6 / 200 x 6.02 x 10-23

10-6 x 10-23 = 10-17

25 / 200 x 6.02 = .7525

.7525 x 10-17 = 7.5 x 10-16 = 75 x 10-15 =

75,000,000,000,000,000 = 75 quadrillion

The only safe amount of mercury is zero, and using mercury as a preservative is reckless, especially since it is given yearly, even to pregnant mothers, even though the package insert admits that the MMR has not been tested for fetal safety in pregnant women. Mercury passes through the placenta and into the fetus. There are flu vaccines which are mercury free.

The flu vaccine is big business, particularly the ones containing mercury. Some 300 million doses are sold, while only 20 million doses of all other vaccines are sold. In 1986 the National Vaccine Injury Compensation Program made vaccine manufacturers immune from most liability, and in 2011 the Supreme Court twisted the plain language of the Vaccine Act to make vaccine manufacturers, hospitals, and physicians completely immune from absolutely ALL liability, reasoning that vaccines in general – using the language of the Court – are “unavoidably unsafe”.

Dr. Geier points out that all flu vaccines are illegal. All vaccines must pass two double blind tests for safety and effectiveness. Because a new vaccine is developed each year in advance of the flu season, and because each vaccine assumes a prediction of which strains of flu will be present, there is no time to two double blind studies, which would take several years.

Our vaccines can contain aluminum, formaldehyde, MSG, antibiotics, and monkey kidney cells. The effort to develop safe and effective vaccines should continue, however, we must admit that we are still at a primitive stage in the development of vaccines, which is why mandating vaccination makes little sense.

The unvaccinated are blamed for spreading disease, however, every person injected with the MMR and other attenuated live virus vaccines develops a vaccine version of the disease, sheds viruses, and can infect others. It is not only the unvaccinated who are spreading measles, which is another reason why mandating vaccination makes little sense.

Measles is not a trifling malady, however, it is not Ebola. Measles cases and deaths from measles declined sharply before the measles vaccine was introduced in 1963. Relatively few die from measles.

Since 1986, Health & Human Services reports 669 deaths from the DTP, 84 deaths from flu vaccines, 80 deaths from the DTaP, 57 deaths from the MMR, 54 deaths from the Hepatitis B vaccine, and many more non-fatal adverse reactions. The science of vaccination is still in a primitive stage, and it is inappropriate for the state to force injection of a possibly harmful drug on behalf of mega-corporations which are completely immune from all liability for adverse reactions.

Further, one who is vaccinated sheds viruses, and so one can be infected not only by those who contract a wild case of measles but also by those recently vaccinated. Moreover, the MMR is not particularly effective “In an October 2011 outbreak in Canada, over 50% of the 98 individuals had received two doses of measles vaccine”.

The Los Angeles Times and the Everett Herald printed an article entitled “Vaccine ignorance proving deadly and contagious”. It was written not by physicians or scientists but by prominent members of the Council on Foreign Relations. It contains numerous inaccuracies – scientific, historical, and legal.

Thinking people support vaccines which are safe, effective, and necessary. Conversely, thinking people should oppose those vaccines which are not safe, not effective, or not necessary.

Law school taught me to break a question down into its component parts: Which vaccines are safe, effective, and necessary, and for whom? How deadly is the disease to be prevented? How likely are adverse reactions and how bad can they be? The CFR authors are uncritical cheer leaders for the $30 billion per year vaccine business, exhorting us to take all recommended vaccines unquestioningly and by the dozens and dozens.

The authors repeat slanders made against Dr. Andrew Wakefield, which were completely false. A recent NOVA special, “Vaccines – Calling the Shots”, repeats these now-disproven slanders, a case of lazy journalism. Recall that Wakefield wrote in the Lancet in 1998 that colitis and autism spectrum  disorders are linked to the combined measles, mumps and rubella (MMR) vaccine then in use.

Wakefield was denounced as a vaccine denier, although he supported and still supports the single dose measles vaccine, as well as other vaccines. He only opposed the MMR. Multiple vaccines given simultaneously can be more harmful than single vaccines. For questioning the safety of one vaccine, Wakefield was “lynched” by GlaxoSmithCline and the medical establishment. Wakefield’s results have been replicated in at least 28 studies done by scientists in other countries. Further, Wakefield has great insight in how to treat children who have had adverse vaccine reactions by treating the gastro-intestinal disease that accompanies adverse reactions.

Wakefield was expelled from the medical profession in Great Britain, however, John Walker-Smith, one of the co-authors of the offending 1998 study, challenged his expulsion and was recently reinstated, an indication that Wakefield could be reinstated if he applied. Wakefield works in Texas as a researcher and is suing Brian Deer, Fiona Godlee and the British Medical Journal for falsely accusing him of fraud.

The CFR authors also seem to be unaware that Wakefield was further vindicated recently when Dr. William Thompson of the CDC “came out”. Thompson was one of the authors of a CDC study which denied any causal link between vaccines and autism. Thompson admitted that in a 2004 article he and other authors had intentionally excluded already collected data, data which would have reversed their published conclusion that there is no vaccine-autism link. The mainstream media has glossed over the story of Wakefield’s vindication and Thomson’s confession.

A mother is not a vaccine denier if she questions the safety of a vaccine containing mercury, aluminum, MSG, antibiotics, eggs, or formaldehyde. Or Beta HCG hormone. Or the urabi virus . She is not a denier if her child is frail or has already had an adverse vaccine reaction and she chooses to opt her child out. She is not a denier if she questions giving children 49 injections of 14 vaccines by age six, including a vaccine at birth for hepatitis B, a disease usually infecting IV drug users. Nor is she a denier if she declines the CDC recommendation that she take the flu vaccine (containing mercury) when she is pregnant, even though the flu vaccine is not tested for safety for pregnant women and fetuses and the FDA advises it be used “only if clearly needed”.

Most are not harmed by vaccines, but some are. For proof read the decisions of the Vaccine Court, which has paid out some $3.0 billion and has acknowledged that specific vaccines have caused specific harms. See the disclosure inserts which comes in vaccine boxes. Ask your pharmacist for copies. Multi-dose flu vaccine contains a whopping 25 micrograms of mercury per dose, included as a preservative. That’s 74 quadrillion atoms of mercury. The single dose version contains under 1.0 micrograms, only 3 quadrillion atoms – still too much for me. The mercury in the flu vaccine passes through the placenta and is especially toxic to fetus and infant because their cells are dividing rapidly. Mercury affects cell division. The use of mercury as a preservative should be banned.

Some vaccines are ineffective. Discover Magazine reported that 73 percent of kids aged 7 to 10 who caught pertussis in 2012 in Washington had been fully vaccinated. The same is true for the measles vaccine. A child vaccinated with a live virus vaccine experiences a mild version of the infection and is thus contagious and infects others. Outbreaks of measles and pertussis probably come from the vaccinated, not from the unvaccinated. The artificial immunity conferred by vaccines wears off, and boosters are required, making vaccines a cash machine that generates $30 billion yearly.

A reasonable question to ask is this: If vaccines worked, those who favor indiscriminant vaccination should not object to those who choose not to be vaccinated.

The problem worsened in 1986. Before that date vaccine liability had always been decided according to state law regardless of which court the case was brought in. 1986 Congress federalized all vaccine liability claims. A law was passed requiring that all claims for vaccine harm go to a special “Vaccine Court”, where there was and is no jury and no pre-trial discovery. The statute of limitations is tricky and short, and the burden to prove a specific vaccination harmed a child is arbitrarily difficult. Vaccine makers are shielded against general liability and even for badly designing a vaccine. Claims are paid out of a fund built up with a tax on each vaccine dose sold. This has led vaccine makers to become reckless, to do insufficient testing of vaccines, and to industrialize the vaccine business.

Before 1986, vaccination had been a technology aimed at the most deadly and contagious diseases. Vaccines were to be put into use only after careful testing. Vaccines were and are needed when a potentially fatal disease progresses so fast the body cannot respond before death occurs. Because adverse reactions are inevitable, vaccines should not be used to prevent diseases which are rarely fatal. However, vaccine makers, newly exempt from all liability, turned necessary vaccination against the most deadly diseases into a mass-production money machine targeted against any and every conceivable disease.

Vaccine makers ship vaccines banned in the West to the Third World, such as the urabi strain MMR vaccine, the dangerous partially attenuated oral polio vaccine used in Pakistan, and a tetanus vaccine which causes miscarriages – none of which would inspire one to trust what vaccine makers say.

All drugs and all vaccines involve some risk which the CDC admits in its assurances that serious harm or death is rare. If the risk of taking the vaccine is greater than the risk of enduring the disease, one has the right to refuse to take the vaccine. Adults can refuse vaccination for themselves. They are the guardians of their children. They know their children’s frailties and previous bad experiences with vaccines. They have the right to opt their children out. If vaccinations work, there should be no objection if some choose not to be vaccinated.

Washington has recently made it more difficult for parents to decline vaccination for their children. Unvaccinated children can be sent home if there is an outbreak of a childhood disease in his or her school, which is odd since the CDC admits, in the case of pertussis, it is vaccinated children who are spreading the disease.

Despite all the evidence that some vaccines cause serious harm, many so-called experts exhort us that all vaccines are safe and effective, and most people stubbornly believe them. Why? Mark Twain explained it best “It’s much easier to fool someone than to convince them they have been fooled.

Examine the evidence for yourself and do your own thinking. Administration of vaccine in mass quantities should not be mandatory, and some vaccines should be banned outright.

The connection between the fluoride scam and the vaccine scam is that they are both run by mega corporations without ethical standards.

We should not be afraid to follow the science where ever it logically goes and be outspoken on other contaminations, such as Roundup, which I just learned is sprayed on non-GMO wheat as a dessicant, so most non-organic bread is loaded with Roundup.

SOTN: Alternative News & Commentary

Australia Determined To Vaccinate By Releast of Aerosolized GMO Vaccine

Australia Determined To Vaccinate By Releast of Aerosolized GMO Vaccine

Dave Mihalovic

Aerial Spraying

© The Viral Post.com

The Office of the Gene Technology Regulator (OGTR) is on its way to approve a licence application from PaxVax Australia (PaxVax) for the intentional release of a GMO vaccine consisting of live bacteria into the environment in Queensland, South Australia, Western Australia and Victoria.

According to the regulator, it qualifies as a limited and controlled release under section 50A of the Gene Technology Act 2000 (the Act).

PaxVax is seeking approval to conduct the clinical trial of a genetically modified live bacterial vaccine against cholera. Once underway the trial is expected to be completed within one year, with trial sites selected from local government areas (LGAs) in Queensland, South Australia, Victoria and Western Australia.

PaxVax has proposed a number of control measures they say will restrict the spread and persistence of the GM vaccine and its introduced genetic material, however there is always a possiblity of these restrictions failing and infecting wildlife and ecosystems.

Aerial vaccines have used in the United States directed towards animals by the use of plastic packets dropped by planes or helicopters.

Sanofi (who is one of the largest vaccine manufacturers in the world) has subsidiary companies such as Merial Limited who manufacture Raboral, an oral live-virus poisonous to humans yet distributed wildlife in the masses.

GMO Vaccine

© The Viral Post.com

In 2006 Michael Greenwood wrote an article for the Yale School of Public Health entitled, “Aerial Spraying Effectively Reduces Incidence of West Nile Virus (WNV) in Humans.”

The article stated that the incidence of human West Nile virus cases can be significantly reduced through large scale aerial spraying that targets adult mosquitoes, according to research by the Yale School of Public Health and the California Department of Public Health.

Under the mandate for aerial spraying for specific vectors that pose a threat to human health, aerial vaccines known as DNA Vaccine Enhancements and Recombinant Vaccine against WNV may be tested or used to “protect” the people from vector infection exposures.

DNA vaccine enhancements specifically use Epstein-Barr viral capsides with multi human complement class II activators to neutralize antibodies. The recombinant vaccines against WNV use Rabbit Beta-globulin or the poly (A) signal of the SV40 virus.

In early studies of DNA vaccines it was found that the negative result studies would go into the category of future developmental research projects in gene therapy.

During the studies of poly (A) signaling of the SV40 for WNV vaccines, it was observed that WNV will lie dormant in individuals who were exposed to chicken pox, thus upon exposure to WNV aerial vaccines the potential for the release of chicken pox virus would cause a greater risk to having adult onset Shingles.

CALIFORNIA AERIAL SPRAYING for WNV and SV40

In February 2009 to present date, aerial spraying for the WNV occurred in major cities within the State of California. During spraying of Anaheim, CA a Caucasian female (age 50) was exposed to heavy spraying, while doing her daily exercise of walking several miles.

Heavy helicopter activity occurred for several days in this area. After spraying, she experienced light headedness, nausea, muscle aches and increased low back pain.

She was evaluated for toxicological mechanisms that were associated with pesticide exposure due to aerial spraying utilizing advanced biological monitoring testing.

The test results which included protein band testing utilizing Protein Coupled Response (PCR) methods were positive for KD-45. KD-45 is the protein band for SV-40 Simian Green Monkey virus.

Additional tests were performed for Epstein-Barr virus capside and Cytomeglia virus which are used in bioengineering for gene delivery systems through viral protein envelope and adenoviral protein envelope technology.

The individual was positive for both; indicating a highly probable exposure to a DNA vaccination delivery system through nasal inhalation.

Pentagon Document Revealed Aerial Vaccination Plans

In the Quarterly FunVax Review in June, 2007, the report lists the objective of a project listed as ID: 149AZ2 as a preparation of a viral vector that will inhibit/decrease the expression of a specific disruption gene (VMAT2) within a human population.

It further indicates in the abstract that six methods of virus dispersal were tested including high altitude release, water supply release, insect transmission, and various methods of diffusion.

Sources:

The Office of the Gene Technology Regulator
VacTruth
Centers for Disease Control and Prevention

Dave Mihalovic is a Naturopathic Doctor who specializes in vaccine research, cancer prevention and a natural approach to treatment.

Polish Study of Neurologic Adverse Events Following Vaccination

Polish Study of Neurologic Adverse Events Following Vaccination

Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 129 Neurologic adverse events following vaccination Sienkiewicz D.*, Kułak W., Okurowska-Zawada B., Paszko-Patej G. Department of Pediatric Rehabilitation of the Medical University of Bialystok, Poland

ABSTRACT __________________________________________________________________________________________

The present review summarizes data on neurological adverse events following vaccination in the relation to intensity, time of onset, taking into account the immunological and non-immunological mechanisms. The authors described the physiological development of the immune system and the possible immune system responses following vaccination. Toxic property of thimerosal – a mercury-containing preservative used in some vaccines was presented. The neurological complications after vaccination were described. The role of vaccination in the natural course of infectious diseases and the current immunizations schedule in Poland was discussed.

Key words: vaccination, neurologic adverse events following vaccination, immunization schedules __________________________________________________________________________________________ *Corresponding author: Department of Pediatric Rehabilitation Medical University of Białystok 17 Waszyngtona str, 15-836 Białystok Poland E-mail: sdorota11@op.pl (Dorota Sienkiewicz) Received: 29.01.2012 Accepted: 22.02.2012 Progress in Health Sciences Vol. 2(1) 2012·pp 129-141. © Medical University of Bialystok, PolandProg Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 130

INTRODUCTION

Adverse reactions In developed countries, the schedules of mandatory and recommended vaccination for children contain more and more components with a specific emphasis on the co-administration of multiple antigens in combined form. This direction on the one hand provides many benefits and on the other carries an increased risk of side effects, the immunopathogenesis of which is not fully explained in many cases [1]. An adverse event following immunization (AEFI) is an undesirable side effect occurring after the administration of a vaccine [2]. It is a temporary, local or general reaction of the organism to an administered vaccine. A postvaccinal complication (PC) is associated with an excessive or pathological reaction with the characteristics of postvaccinal disease, which in extreme cases can lead to permanent damage, threat to life or even death [3]. Complications affecting the nervous system raise the most controversy; the more so, as the children subjected to vaccination are healthy.

In annex no. 1 to the Ordinance of the Minister of Health of 23rd December 2002 on adverse events following vaccination (Journal of Law from 31/12/2002, no. 241, item 2097, as amended. Journal of Law from 2005, no. 232, item 1973), the following categories of AEFI are presented [4].

1) Local reactions, including:

  • a) local reactions after the BCG vaccine,
  • b) swelling,
  • c) lymphadenopathy,
  • d) abscess at the injection site;

2) Postvaccinal adverse events of the central nervous system:

  • a) encephalopathy,
  • b) febrile convulsions,
  • c) non-febrile convulsions,
  • d) paralytic poliomyelitis caused by vaccine virus,
  • e) encephalitis,
  • f) meningitis,
  • g) Guillain – Barre syndrome;

3) Other adverse events following immunization:

  • a) joint pain,
  • b) hypotonic-hyporesponsive episode
  • c) fever above 39⁰C
  • d) thrombocytopenia,
  • e) continuous inconsolable crying.

Other classifications of postvaccinal reactions can be found in the literature, some of which put an emphasis on the neurological symptoms, while others emphasize the immunological mechanisms.

Byers et al. describing neurological complications, have included as “minor” – mild or severe postvaccinal reactions, occurring up to 48 hours after injection and disappearing without leaving permanent sequelae, the following:

  • prolonged crying,
  • restlessness and hyperactivity,
  • apathy with increased sleepiness,
  • high body temperature,
  • a temporary mild increase in intracranial pressure manifested by a throbbing crown of the head,
  • “cerebral cry” (sometimes included among “major” complications) [5-7].

Among the “major” neurological complications, usually manifesting more than 48 hours after vaccination and which might be the cause of permanent damage to the central nervous system (CNS), the following are listed:

  • seizures – especially if there is no increase in body temperature,
  • hypotonic-hyporesponsive episodes,
  • postvaccinal encephalitis,
  • postvaccinal encephalopathy [6, 8-11]
  • and autism [10, 12-14].

Konior and Strózik [7] have proposed their own classification of postvaccinal reactions taking into account the contribution of the immune system in the vaccinated children. They divided the adverse events into two groups:

1. related to the immune system – patients with immunodeficiencies (mainly cellular) and atopic patients with hypersensitivity to certain vaccine components

2. unrelated to the immune system – patients whose postvaccinal reactions may be related to the toxic effects of the vaccine components or may result from the vaccine virus turning virulent, resulting in complete or abortive symptoms of the disease.

Another classification of adverse events following vaccination distinguishes:

Local postvaccinal reactions (redness, swelling, pain at the injection site) occurring particularly often after the administration of live vaccines (10.8% -15.5% of reports) [15]

 Generalized postvaccinal reactions (fever, malaise, muscle pain, joint pain, headaches, flu-like symptoms, local lymphadenopathy, allergic reactions) – usually disappear spontaneously within 3 days of vaccination, do not require treatment [16].

 Early postvaccinal complications – anaphylactic reaction, described in one in about 1 million of vaccinated individuals, occurs most often after immunization against typhoid, tetanus, pertussis, measles, mumps, rubella [16].

 Late and long-term complications – determined by different immunological mechanisms, occur most often after the administration of preparations containing live micro-organisms (e.g., flaccid paralysis after an oral poliovirus vaccine OPV – 10 individuals annually per 1 million people vaccinated) [16].

Prog Health Sci 2012, Vol 2 , No1

Neurologic adverse events vaccination 131

Reports in many Polish and foreign medical journals lead us to conclude that postvaccinal complications among children can be observed in sporadic cases and that they are disproportionate to the benefits of vaccination in the elimination of dangerous diseases in childhood. This article focuses on several aspects related to overall immunization, including: the physiological development of the immune system, the possible immune system responses following vaccination, the site of vaccination in the natural course of infectious diseases and the current immunization schedule in Poland compared with other countries. The immune system in terms of vaccination

Physiology

Immune system functioning in neonates is characterized by complex mechanisms to adapt to the changed conditions of postnatal life. In infancy and early childhood, the individual components of specific and nonspecific immunity gradually develop and mature [17]. The humoral immunity of neonates is acquired and is associated with active transport of maternal immunoglobulin G through the placenta (starting from the end of the first trimester of pregnancy) mainly in the last 5-6 weeks of pregnancy. A neonate’s humoral response is therefore a state of physiological dysimmunoglobulinemia, i.e. it has an average concentration of its own IgG, minimal or low concentrations of IgA, IgM, IgE, IgD [13, 14]. The level of maternal IgG gradually decreases, while the level of the child’s IgG increases reaching approximately 60% of the adult level after 12 months. In the 2-3 month of life, an intersection of curves takes place – the declining curve of maternal IgG concentration and the increasing curve of infant IgG concentration (graph). The infant’s IgG level is the lowest then [18].

Levels of antibodies in the blood serum of the fetus, neonate and infant [18] From a physiological point of view, according to Jakóbisiak’s [18] classification, the group of secondary immunodeficiency disorders includes conditions such as pregnancy and conditions associated with age (neonates, the elderly). Premature babies are a specific group, whose shortened period of maternal IgG influx leads to compromised anti-infective immunity. On the other hand, according to the author, on account of the existing maternal antibodies, vaccination against certain microorganisms administered shortly after birth does not lead to long-lasting immunity. It should be emphasized that the immune system reaches full immunoregulatory and defensive maturity at about 3 years of age [19]. It is well established that early-life immune responses are weaker and of shorter duration than elicited in immunologically mature hosts. Consequently, vaccine efficacy in early infancy (particularly in the first 6 months of age) is limited [20]. Thus, in oder to provoke and sustain an adequate B-cell immune response in a neonate, strong immune adjuvants and repeated closely spaced booster doses are needed [21]. The problem with this approach is two-fold. First, experimental evidence clearly shows, that simultaneous administration of as little as two to three immune adjuvants, or repeated stimulation of the immune system by the same antigen can overcome genetic resistance to autoimmunity [22]. Second,while it is generally accepted that potency and toxicity of immune adjuvants must be adequately balanced so that the necessary immune stimulation is achived with minimal side effects, in practical terms, such a balance is very difficult to achieve. This is because the same adjuvantedmediated mrchanisms which drive to the immunestimulatory effects of vaccines have the capacity to provoke a variety of adverse reactions [23, 24] Vaccinations and immune response A vaccine is defined as a biological preparation containing antigen(s) of microorganisms that cause specific stimulation of the immune response after administration which protects against infection by this microorganism, with safety precautions taken during administration [18, 25].

A vaccine may contain:

  • 1. Microorganism antigens – bacterial or viral (live-attenuated, dead), isolated antigens – proteins, polysaccharides, DNA and anatoxins (diphtheria, tetanus) with retained immunegenicity but devoid of pathogenic properties,
  • 2. Suspension: water, physiological saline, substrate protein, e.g. egg white, gelatin,
  • 3. Preservatives: thiomerosal (mercury), antibiotics, phenol,
  • 4. Adjuvants, the aim of which is to enhance the immunogenicity of the vaccine – aluminum hydroxide or aluminum phosphate are the most commonly used.

Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 132

According to the literature [18], it is believed that vaccines containing live microorganisms are among the most effective means of inducing immunity against infectious disease. Attenuated microorganisms (viruses, BCG mycobacteria) retain the ability to replicate in host cells, which stimulates cytotoxic T lymphocytes (Tc, CD8 +) that destroy cells infected by them. The way of impact of isolated antigens or antigens derived from whole inactivated microorganisms is different. In this case, a stimulation of the auxiliary Th (CD4+) lymphocyte response takes place. Th lymphocytes contain two distinct – in functional terms – subpopulations: Th1 and Th2. According to Jakóbisiak – with some simplification – it can be assumed that the Th1 lymphocytes perform auxiliary functions in cell-type response and Th2 in humoral response [18]. The mechanism of immune response to various types of vaccine antigens, especially to antigens in multicomponent vaccines, is not fully understood and researched.

The vaccination-stimulated Th2 pathway responsible for the production of antibodies, the pathway which predominates in neonates and infants, in the absence of an adequate balance of Th1 response may lead to the development of allergic reactions [25]. This is symptomatic of the fact that allergic diseases are often referred to as “an epidemic of the XXI century” [26, 27]. As stated in the “European Allergy White Paper”, the clinical symptoms of allergy are present in 35% of the population of developed countries, and according to the ISAAC (The International Study of Asthma and Allergies in Childhood) as many as 40%. Allergy is one of the major health problems on par with AIDS, cancer, cardiovascular diseases, injuries and accidents [28 – 30]. According to other authors, a restriction of the natural environmental infections stimulating Th1 response as well as change of their natural course resulting from mass immunization, an increase in general hygiene and widespread use of antibiotics (“Hygiene Theory”) inhibiting and delaying the adjustment of Th2/Th1 could theoretically also contribute to the growth of the risk of allergic diseases [31, 32]. A confirmation of this thesis was the study of Swiss children from anthroposoic backgrounds, in which significantly less atopy was observed than in children from other backgrounds. In this group, a positive correlation of diseases with the MMR vaccination was found [33]. In addition, in a series of papers, Silverberg et al. have shown that wild type varicella zoster virus infection (WTVZV), but not varicella vaccine (VV), protects against asthma and atopic dermatitis (AD) in young children [34, 35]. The protective effect of WTVZV was attributed to its beneficial effect on stimulating Th1-primed immune responses and suppressing allergy-promoting Th2 responses. According to Silverberg et al. [34], ―The introduction of widespread varicella vaccination and resultant decline of WTVZV in the United States may be a contributing factor in the increased prevalence of AD [atopic dermatitis] over the past few decades.‖ Notably, other than not providing an effective stimulus for proper immune system development, recent research has shown that vaccines are actually capable of disrupting it. For example, annual vaccination against influenza has been shown to hamper the development of virusspecific CD8+ T-cell immunity in children [36] From the above observations it is clear that the proper functioning of the immune system involves a delicate balance between the two arms of the immune equilibrium (Th1/Th2), and its tilt to either side can be harmful for the body [30]. Furthermore, it appears that the necessary Th1/Th2 balance is better provided by natural challenges (i.e., in a form of relatively benign childhood diseases such as chickenpox and mumps) rather than vaccination. Recent research by Singh of the International Institute for Brain Research in the USA confirm the veracity of this statement. In the study, serum and cerebrospinal fluid (CSF) were analyzed in terms of viral and autoimmune markers in Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 133 patients with autism compared with a group of healthy children – both groups were vaccinated with MMR (measles, mumps, rubella vaccine) [37]. This is the first of this type of research examining a positive correlation between viral factors (viral serology) and autoimmune factors (brain autoantibodies). It was found that higher levels of measles antibodies were accompanied by Myelin Basic Protein (MBP) autoantibodies in children with autism (Figure.3). A similar serology was found in CSF. Fig. 3. Correlations between MMR antibodies and MBP autoantibodies in autistic and healthy children. (Source: [37] Singh VK. Phenotypic expression of autoimmune autistic disorder (AAD): A major subset of autism. Annals of Clinical Psychiatry, 2009, 21, 3,148-161; with permission: Healthy Impressions) The results in Table 1 show a comparative study of antibodies against other viral pathogens in the studied population of children which confirmed the pathogenic role of the measles strain.

Table 1. Blood serum levels of antiviral antibodies in healthy and autistic children Virus antibody (units)

Measle s Mu mps Rub ella HH V-6 CMV EBV EA EBN A VC A

  • Normal children 3.3±0. 1 2.5± 0.2 3.2± 0.2 1.6± 0.6 0.28 ±0.4 0.5±0 .04 1.2 ±0.2 1.8± 0.3 (n=32) (n= 30) (n=4 5) (n= 37) (n=3 0) (n=4 4) (n=4 4) (n= 44)
  • Autistic children 4.2±0. 1* 2.6± 0.3 3.3 ±0.1 2.2± 5.3 0.23+ 0.3 0.6 ±0.04 0.9± 0.2 1.4± 0.2 (n=87) (n= 32) (n=7 4) (n= 45) (n=3 0) (n=4 4) (n=4 4) (n= 44) p value .003* .76 .98 .5 .37 .76 .21 .15

(Source: [37] Singh VK. Phenotypic expression of autoimmune autistic disorder (AAD): A major subset of autism. Annals of Clinical Psychiatry, 2009, 21, 3,148-161; with permission: Healthy Impressions)

CMV: cytornegalovirus; EA: early antigen; EBNA: Epstein-Barr nuclear antigen; EBV: Epstein-Barr virus; HHV-6: human herpesvirus-6; VCA: viral capsid antigen; *Student t test was used to evaluate significance at a p value < 0.05 Significantly elevated levels of cytokines – IL-2, IL-12, IFN-γ (factors triggering autoimmune response) – and acute phase proteins were also found in patients [37].

According to the authors of this study, subtle changes in the child’s developing brain caused by an autoimmune reaction, changes in the myelin sheath, may ultimately lead to impairment Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 134 of higher brain functions such as speech, communication, social interaction, as well as other neurological symptoms occurring in children with autism. In this study, the measles viruses were researched, but under the immunization program children also receive vaccinations with simultaneous administration of several viral components. What then occurs in the brain of a child? Presently, there are no studies in this area.

In an earlier study concerning postvaccinal adverse events of the immune system, Mannhalter et al. [38] presented an analysis of T lymphocyte (Th1/Th2) subpopulations in healthy adults before and after the administration of a vaccine containing the tetanus toxin. The result was a decrease in the Th1/Th2 ratio after vaccination, with maximum intensity 3 to 14 days after injection. These reports present a picture of neuroimmune disorders which may be the result of vaccinations carried out on an increasingly wider scale. A clear answer to this hypothesis would require both large-scale epidemiological studies as well as in-depth laboratory research. In Poland, multi-antigen combination vaccines are commonly administered at full cost with parental consent. Most often children are immunized at the same time with: diphtheria and tetanus toxoid, acellular pertussis antigen, polio and H.influenzae (Infanrix-IPV+Hib, Pentaxim vaccines) or with an additional antigen of hepatitis B virus (Infanrix hexa vaccine). These vaccinations are repeated from the second month of life 3 times every 6-8 weeks. The recommended vaccinations against rotavirus and pneumococcal (2-3 doses) are also proposed to children under 6 months of age. Together with the tuberculosis and hepatitis B vaccinations administered in the first 24h of life, an infant receives 24-26 doses of xenogenic antigens. According to Tsumiyama et al. [39] systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host’s immune ‘system’ by repeated immunization with antigen. Indeed, in adults multiple vaccinations have been associated with a variety of autoimmune phenolmena [40 – 42], yet children are regularly exposed to a much higher burden of vaccines than adults under the assumption that such exposures are safe [43] . Vaccinations as an important “training” for the immune system lower its threshold of defense responses, which is a measure to prevent the development of infectious diseases. However, a question arises: how will the not fully mature, still developing immune system of a healthy child and the still forming central nervous system respond to such intense stimulation? Is it able to correctly respond with the same protective effect to so many different stimuli? Do the multi-antigen vaccine side effects change compared to the previously used vaccinations and how? Thus far, these questions lack clear answers. Nonetheless, it is important to emphasize that a burgeoning body of evidence shows that immune molecules play integral roles in CNS development, affecting processes such as neurogenesis, neuronal migration, axon guidance, synaptic connectivity and synaptic plasticity [44 – 46]. Despite the dogma that peripheral immune responses do not affect CNS function, substantial evidence points exactly to the contrary [44, 47, 48]. Thus, it is not reasonable to assume that manipulation of the immune system through an increasing number of vaccinations during critical periods of brain development will not result in adverse neurodevelopmental outcomes [43, 49] Neurological symptoms following vaccination

In recent years, attention has been brought to the mercury contained in vaccines as a component with toxic and allergic properties. The mercury compound is found in organic combinations in the form of sodium salt – thimerosal (sodium ethylmercuriothiosalicylate, merthiolate). The incidence of allergy to this compound is variously estimated from 13% in the Netherlands to 21% in Austria. Vaccinations are a primary cause of the initial allergic reactions to thimerosal [50]. Mercury’s neurotoxicity (accumulation in the brain), cardiotoxicity, hepatotoxicity, nephrotoxicity, immunotoxicity, and carcinogenicity are mentioned as its toxic activity. It causes, among others, developmental disorders in children and neurodegenerative diseases in adults [7]. According to researchers [51, 52], a manifold incidence increase of psychoneurological diseases such as autism, ADHD, mental retardation, epilepsy and others have been observed all over the world over the past twenty years. As stated, from the 1990s new vaccines for infants containing thimerosal began to be used in America. In the DTP, Hib and Hep B vaccines, children received a dose of 62.5 ug of mercury, which is 125-fold more than the dose considered safe (0.1ug/kg/day). These reports were the reason that Scandinavian countries already prohibited the use of mercury in 1990 [53]. In 2005, a paper was published which describes the sudden death (SUD – Sudden Unexpected Death) of 19 infants within a few hours/days after vaccination with two hexavalent vaccines (DTP-Hib-HepB-IPV). The healthy prior to vaccination children died as a result of postvaccinal cerebral and lung edema and heart attacks. As the authors conclude, despite the lack of direct evidence for a causal relationship of the described SUDs with vaccination, it is a signal that brings to attention the need to monitor the course of vaccination and its complications [54].Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 135

In another study from 2004, Geier et al. [12] confirmed through epidemiological research the direct relationship between increasing doses of thimerosal and the incidence of autism in children in the US from the late 1980s through the mid- 1990s. In addition, there was a potential correlation between the number of primary pediatric measlescontaining vaccines (MMR) administered and the prevalence of autism during the 1980s. Geier et al. [12] also found a statistically significant odds ratios for the development of autism following increasing doses of mercury from thimerosal-containing vaccines (birth cohorts: 1985 and 1990-1995) in comparison to a baseline measurement (birth cohort: 1984). The contribution of thimerosal from childhood vaccines (>50% effect) was greater than that of the MMR vaccine on the prevalence of autism observed in the study. In Poland, according to the documents “Characteristics of Pharmaceuticals”, there are currently several permitted vaccines with significant thimerosal (THIM) content. These are: Euvax (Hepatitis B, LG Life Sciences, Korean manufacture) – 0.01% THIM-50μg/dose, DT (Biomed, Krakow) – 50μg/dose, Td (Biomed, Krakow) – 50μg/dose, DTP (Biomed, Krakow) – 50μg/dose, D,d (Biomed, Krakow) – 50μg/dose, TT (Biomed, Krakow) – 50μg/dose [4, 55]. The frequency of observed reactions and complications depend on the general condition, especially neurological, of the child, the age, immunological resistance status as well as family and genetic load. In the literature, neurological symptoms are usually connected with the pertussis component of the vaccines, including: cerebral cry, according to Cody, occurs in 1:1000 of vaccinated subjects; seizures – mild, feverish – triggered by the pertussis endotoxin, in 10% of vaccinated subjects the convulsions occur without elevated body temperature, and severe seizures occur according to Waller et al. in 1 in 106,000 children [25]. In serious complications, such as encephalitis (about 2.9/10,000,00 of those vaccinated with DTP), encephalopathy (1:140,000 – 1:300,000 of the vaccinated), which may result in mental retardation, recurrent seizures, epilepsy – particularly myoclonic and Lennox-Gastaut Syndrome, changes in the central nervous system comparable to those which occur in the course of meningitis and encephalitis were reported. In the early stages, perivascular lymphocytic infiltration and demyelination outbreaks were observed, then myelin atrophy with intact neuron axial fiber, degenerated microglia and macrophage cells. Some experimental studies suggest the pertussis toxin, which through the membrane receptors causes inhibitory neurotransmitter dysfunction and induces activity of excitatory neurotransmitters [56, 57]. In 2010, a case of a 6-month-old previously healthy boy admitted to hospital on day 6 after vaccination with DTwP (whole cell) was described. The child was in a coma, hypotonia, with focal clonic seizures. MRI of the central nervous system using proton spectroscopy revealed acute necrotizing encephalopathy [58]. Previously, epileptic seizures in children with asymptomatic CMV infection which occurred after vaccination with DTwP and OPV had also been described. In the case of hepatitis C virus (HCV) infection, DTaP (acellular) and IPV (inactivated) vaccinations are recommended [59]. As stated in the Polish literature, acellular vaccines are much better tolerated than whole cell – the risk of fever after the first dose is reduced by over 99%, the risk of hypotonic-hyporesponsive episodes by 56%, similar to seizures, and the risk of inconsolable crying after the first dose is reduced by 87% [4]. According to the current vaccination schedule in Poland, infants receive the first three doses of DTwP in the first 6-8 weeks of life every 6-8 weeks, the 4th dose in the 16th-18th month of life, and a DTaP booster at 6 years of age. Given the often reported neurological complications after whole-cell pertussis (DTwP, DTP) vaccine, most developed countries – European and the US – have introduced changes in their immunization schedules and the safer acellular (DTaP) vaccines are administered to children. Of these countries, the only exceptions are: Bulgaria, Malta and Poland. In Poland, the safe vaccine is paid in full.

Other neurological complications associated with the administered vaccination are listed, among others, as follows:

  • multiple sclerosis after hepatitis B vaccine [60],
  • Guillain-Barre syndrome – after vaccination against influenza, hepatitis, meningitis C, polio and HPV vaccines [61-65],
  • transverse myelitis as a result of vaccination against cholera, typhoid, polio, and influenza,
  • flaccid paralysis, meningitis, encephalitis, convulsions and facial palsy after live polio vaccine [65, 66],
  • rapid progression of retinopathy in premature infants after BCG vaccination [67].

Monitoring In the case of AEFI, the obligation of notification was described in article 21 of the Preventing and fighting infections and infectious diseases in humans Act. According to the Act, a physician who recognizes or suspects the occurrence of AEFI is required, within 24 hours after concluding the suspicion, to notify the State Sanitary Inspector of the suspected case [3]. In order for that to be possible, the child’s guardian must also be accurately informed about the adverse symptoms following vaccination that may occur, then report the problem to the doctor or nurse who will take further steps.

There was an attempt to trace the actual scale of the adverse events following vaccination reported by nurses and doctors. Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 136  The monitoring system was introduced in Poland in 1996 and is based on the WHO recommendations. In the Zieliński study, the number of AEFI reported in 1996-2000 from different provinces was analyzed and clear differences regarding the frequency of recorded entries were found. As the authors write, “they met astonishing examples of ignorance of the medical staff, including specialists, in their duty to report the AEFI” in their epidemiological practice [68]. On the other hand, there is no real possibility of laboratory tests to confirm a causal relationship between the clinical picture and the used vaccine. For example, only a few research laboratories in Poland, of the highest reference level, posses the microbiological methods for distinguishing mycobacteria from the BCG vaccine from other species of the Mycobacterium tuberculosis strain [69]. There are also no reports in the literature (except those listed above) of research work in immunology in the context of reactions following vaccination. It should also be noted that in more developed countries, there is little incentive for doing appropriate follow-up and laboratory tests on individuals who suffered serious adverse reactions following vaccinations [70]. The reason for such oversight is likely due to the fact that historically, vaccines have not been viewed as inherently toxic by the regulatory agencies [68] The resulting lack of evidence of causality between vaccinations and serious adverse outcomes has thus been filled with an assumption that vaccines are safe [71]. Natural history of infectious diseases/ immunizations Based on statistics from the Federal Statistics Office in Wiesbaden, Buchwald published a paper containing long-term observations of morbidity and mortality from infectious diseases. It is interesting that in recent decades a decrease of infectious diseases was generally reported, which took place before the introduction of inoculations against these diseases. According to a 2002 report from Lancet Infectious Diseases [72] ―the weight of evidence collectively suggests that personal and environmental hygiene reduces the spread of infection‖ and ―Thus results from this review demonstrate that there is a continued, measurable, positive effect of personal and community hygiene on infectious‖. The same report showed that the crude death rate from infectious diseases decreased to nearly negligible levels long before introduction of universal vaccination practices. Currently, the developed countries introduce increasingly complex vaccination schedules. Forty years ago, children were immunized against five diseases (diphtheria, tetanus, pertussis, polio, smallpox), today this number has increased to eleven. At the same time, as mentioned previously, repeatedly administered multi-antigen vaccines are recommended. Doctors and researchers point to the worsening state of health of the child population since the 1960s, which coincided with increasingly introduced vaccinations. Allergic diseases, including asthma, autoimmune diseases, diabetes and many neurological dysfunctions – difficulty in learning, ADD (attention deficit disorder), ADHD (attention deficit hyperactivity disorder), seizures, and autism – are chronic conditions, to which attention has been brought [73]. Proposals for modification of the vaccination schedule European countries have different models of vaccination that have been modified in recent decades. In Scandinavian countries, which have the lowest infant mortality, vaccinations are voluntary and infants receive their first vaccination at 3 months of age. In the first year of life, they receive 9 recommended vaccinations, and at 18 months – MMR. The acellular pertussis vaccine (DTaP) is used, as well as IPV. BCG and Hepatitis B vaccines are administered to children from high risk groups. Similar vaccination schedules exist in other European countries, where the vaccination of neonates was abandoned and a ban on the use of thimerosal in vaccines was introduced [4, 74]. Note also that Scandinavian countries have the lowest rates of autism compared to other developed countries in which children are vaccinated much earlier and with greater number of vaccines [49]. Professor Majewska – a neurobiologist, Director of the Marie Curie Chairs Program at the Department of Pharmacology and Physiology of the Nervous System in Warsaw – together with pediatricians, drafted a proposal for changes to the vaccination program in Poland, which is based on an analysis of programs in other European Union countries. The propositions are as follows:

1. Eliminate thimerosal from all vaccines.

2. Discontinue the immunization of infants with the hepatitis B vaccine (vaccinate only newborns at high risk, i.e. of infected mothers).

3. Discontinue BCG vaccination of neonates (use only in regions where the percentage of TB patients is over 40 per 100 thousand).

4. Begin vaccination from 4 months old in the remaining group of children.

5. Discontinue the whole cell pertussis vaccine.

6. Give a maximum of three types of vaccines in one day.

7. Discontinue the administration of live virus vaccines or give them one at a time at safe intervals.

8. Make monovalent vaccines accessible.

9. Commitment of the doctor administering the vaccine to conduct a preliminary interview with the parents about allergies, asthma and other autoimmune diseases and postvaccinal complications in family members, allowing them to predict whether a given child may experience severe postvaccinal reactions. Such a child should have an individual, very careful vaccination program developed.

10. Monitor the health status of children after vaccination in order to notice life- or healththreatening conditions in time.

11. Create a national program for compulsory registration of postvaccinal complications and deaths. These data should be reported to the WHO and information about complications should be provided in the child’s health record book [51]. Prog Health Sci 2012, Vol 2 , No1 Neurologic adverse events vaccination 138

CONCLUSIONS

Despite the assurances of the necessity and safety of vaccinations, there are more and more questions and doubts, which both physicians and parents are waiting to be clarified. This paper describes several aspects of the immunization program of children. It includes:

  • the physiological development of the immune system,
  • the immunization schedule adopted in Poland in comparison with other countries,
  • adverse reactions and complications following vaccination described in scientific publications,
  • the natural course of infectious diseases in conjunction with the vaccination programs implemented
  • and the problem of reporting adverse reactions following vaccination by medical personnel and parents.

The proposal for changes in vaccination in Poland cited at the end of this paper is, according to the authors, part of the answer to the concerns and doubts. A second part would be extensive neuroimmunological research confirming or excluding the relationship of vaccines with the reported adverse events (early, late/long-term) and chronic diseases whose upward trend has been observed in recent decades in children. It seems that it would be worthwhile to apply the precautionary principle – the ethical principle (from 1988) according to which if there is a probable, although poorly known, risk of adverse effects of new technology, it is better not to implement it rather than risk uncertain but potentially very harmful consequences.

ACKNOWLEDGMENTS

We are grateful to Mrs. Ursula HumienikDworakowska for the translation of this article.

Conflicts of interest

We declare that we have no conflicts of interest.

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